新产品编号:796255
4-(三氟甲氧基)-N-[2-(三氟甲基)苄基]苯扎脧Chemical Name: 4-(Trifluoromethoxy)-N-[2-(trifluoromethyl)benzyl]benzamidine
CAS No. 305339-41-7
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Originator)
合成路线:4-Trifluoromethoxybenzonitrile (I) is converted to the corresponding imidate (II) with an ethanolic solution of HCl.Condensation of imidate (II) with 2-trifluoromethylbenzylamine (III) furnishes the target amidine.(1,2)
📌 参考资料/链接：
参考文献标题:Aryl amidines,compsns.containing such cpds.and methods of use
文献作者:Curtis,N.R.; Kulagowski,J.; Liverton,N.J.; Claiborne,C.F.; Libby,B.(Merck & Co.,Inc.)
参考来源:EP 1178792; JP 2002544162; US 6319944; WO 0067751
📄 详细内容
合成路线:4-Trifluoromethoxybenzonitrile (I) is converted to the corresponding imidate (II) with an ethanolic solution of HCl.Condensation of imidate (II) with 2-trifluoromethylbenzylamine (III) furnishes the target amidine.(1,2)
参考文献标题:Orally efficacious NR2B-selective NMDA receptor antagonists
文献作者:Claiborne,C.F.; McCauley,J.A.; Libby,B.E.; Curtis,N.R.; Diggle,H.J.; Kulagowski,J.J.; Michelson,S.R.; Anderson,K.D.; Claremon,D.A.; Freidinger,R.M.; Bednar,R.A.; Mosser,S.D.; Gaul,S.L.; Connolly,T.M.; Condra,C.L.; Bednar,B.; et al.
参考来源:Bioorg Med Chem Lett 2003,13(4),697
产品链接: CAS No. 305339-41-7››