JTT-608

4-(4-甲基环己基)-4-氧代丁酸Chemical Name: trans-4-(4-Methylcyclohexyl)-4-oxobutanoic acid
CAS No. 195137-72-5, 195138-09-1 (cis-isomer), 220203-23-6 (undefined isomer)
项目整合开发状态: Phase I
项目研究机构: Japan Tobacco (Originator)
合成路线:The reaction of di-tert-butyl malonate (I) with ethyl 2-bromoacetate (II) by means of NaH in THF gives di-tert-butyl 2-(ethoxycarbonylmethyl)malonate (III),which is condensed with trans-4-methylcyclohexylcarbonyl chloride (IV) by means of NaH in THF,and without isolation is treated with p-toluenesulfonic acid in refluxing toluene to afford trans-4-(4-methylcyclohexyl)-4-oxobutyric acid ethyl ester (V).Finally,this compound is hydrolyzed with aqueous NaOH.