SK&F-94120
4-(4-乙基环己基)-4-甲基戊烷-2-酮Chemical Name: 5-(4-Acetamidophenyl)pyrazin-2(1H)-one
CAS No. 89541-55-9
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:1) By condensation of 2 chloropyrazine (I) with N-acetylphenylhydroxylamine (II) by means of NaH in DMF (or NaOH in DMF - water; or with K2CO3 in acetone).
合成路线:2) The condensation of (I) with benzyl-N-hydroxy-N-phenylcarbamate (III) in ethanolic KOH gives 5-[4-(benzyloxycarbonylamino)phenyl]pyrazin-2(1H)-one (IV),which is hydrolyzed witn HBr in acetic acid yielding 5-(4-aminophenyl)pyrazin-2(1H)-one (V).Finally,this compound is acetylated with acetic anhydride.
📌 参考资料/链接：
参考文献标题:5-(4-Nitrophenyl)-2(1H)-pyrazinones
文献作者:Coates,W.J.(SmithKline Beecham plc)
参考来源:EP 0096517; US 4514568; US 4556711
📄 详细内容
合成路线:1) By condensation of 2 chloropyrazine (I) with N-acetylphenylhydroxylamine (II) by means of NaH in DMF (or NaOH in DMF - water; or with K2CO3 in acetone).
合成路线:2) The condensation of (I) with benzyl-N-hydroxy-N-phenylcarbamate (III) in ethanolic KOH gives 5-[4-(benzyloxycarbonylamino)phenyl]pyrazin-2(1H)-one (IV),which is hydrolyzed witn HBr in acetic acid yielding 5-(4-aminophenyl)pyrazin-2(1H)-one (V).Finally,this compound is acetylated with acetic anhydride.
参考文献标题:SK&F-94120
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(2),129
产品链接: CAS No. 89541-55-9››