YM-976

4-(3-氯苯基)-1,7-二乙基吡啶并[2,3-d]嘧啶-2(1H)-酮Chemical Name: 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
CAS No. 191219-80-4
项目整合开发状态: Phase I
项目研究机构: Yamanouchi (Originator)
合成路线:3-Cyano-6-ethyl-2-pyridone (I) was chlorinated using phosphorus oxychloride to afford the chloropyridine (II).Subsequent addition of the Grignard reagent prepared from 3-bromochlorobenzene (III) to the cyano group of (II) produced ketone (IV).This was treated with ethylamine to give the aminopyridine derivative (V).Finally,the reaction of (V) with chlorosulfonyl isocyanate produced the target pyridopyrimidinone.