项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Pibutidine hydrochloride, IT-066

3-氨基-4-[[(Z)-4-[4-(哌啶-1-基甲基)吡啶-2-基]氧基丁-2-烯基]氨基]环丁-3-烯-1,2-二酮盐酸盐 3-氨基-4-[[(Z)-4-[4-(哌啶-1-基甲基)吡啶-2-基]氧基丁-2-烯基]氨基]环丁-3-烯-1,2-二酮 Chemical Name: 3-Amino-4-[4-[4-(1-piperidinylmethyl)-2-pyridyloxy]-2(Z)-but...
参考文献标题:Pyridyloxy derivs.
文献作者:Nohara,F.; Fujinawa,T.(Ikeda Mohando)
参考来源:AU 8548136; EP 0177016; ES 8701161; JP 1986085365; JP 1986207375; JP 1991261766; US 4710498

SUN-N4057

3-氯-4-[4-(3',6'-二氢-2,4'-联吡啶-1'(2'H)-基)丁基]-1,4-苯并氧氮杂卓-5(4H)-酮Chemical Name: 3-Chloro-4-[4-[4-(2-pyridyl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]-1,4-benzoxazepin-5(4H)-one dihydrochloride dihydrate
CA...
参考文献标题:Benzoxazepine derivs.,salts thereof,and drugs containing the same
文献作者:Tatsuoka,T.; Kamei,K.; Maeda,N.; Inoue,T.; Nishimura,M.; Hirotsu,I.(Suntory Ltd.)
参考来源:EP 0755930; WO 9624594

FR-188582

3-氯-5-(4-甲基磺酰基苯基)-1-苯基吡唑Chemical Name: 3-Chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-1H-pyrazole
CAS No. 189699-82-9
项目整合开发状态: Preclinical
项目研究机构: Fujisawa (Originator)
合成路线:The cyclizati...
参考文献标题:1,3,5-Trisubstd.pyrazoles for treatment of inflammation
文献作者:Matsuo,M.; Okumura,K.; Ogino,T.; Nakamura,K.; Nishimura,H.; Harada,K.; Hotta,Y.; Tsuji,K.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0856000; JP 1999513403; WO 9713755

新产品编号:337475

3-环己基-5,6-二甲基噻吩[2,3-d]嘧啶-2,4(1H,3H)-二酮Chemical Name: 3-Cyclohexyl-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No. 203808-33-7
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi ...
参考文献标题:Synthesis of new thieno[2,3-d]pyrimidine-2,4(1H,3H)-diones with analgesic and anti-inflammatory activities
文献作者:Romeo,G.; et al.
参考来源:Arzneim-Forsch Drug Res 1998,48(2),167-172

CL-218872

3-甲基-6-(3-[三氟甲基]苯基)-1,2,4-噻唑并-(4,3-b)吡嗪Chemical Name: 3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
CAS No. 66548-69-4
项目整合开发状态: Biological Testing
项目研究机构: Wyeth Phar...
参考文献标题:CL-218,872
文献作者:Owen,R.T.; Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1983,8(3),191

Combretastatin A-1 phosphate , OXI-4503, CA1P

3-甲氧基-6-[(Z)-2-(3,4,5-三甲氧基苯基)乙烯]-1,2-苯二酚二酚(二氢磷酸盐)四钠盐Chemical Name: 3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]-1,2-benzenediol bis(dihydrogen phosphate) tetrasodium salt
CAS No. 288847-34-7, ...
参考文献标题:Antineoplastic agents 429.Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs
文献作者:Pettit,G.R.; Lippert,J.W.III
参考来源:Anti-Cancer Drug Des 2000,15(3),203

BIA-3-202

3-硝基-5-苯基乙酰基邻苯二酚Chemical Name: 1-(3,4-Dihydroxy-5-nitrophenyl)-2-phenyl-1-ethanone
CAS No. 274925-86-9
项目整合开发状态: Phase I
项目研究机构: Bial (Originator), Portela (Originator)
合成路线:Protection of ...
参考文献标题:Substd.2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones,their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compsns.containing them
文献作者:Benes,J.; Soares da Silva,P.M.V.A.; Learmonth,D.A.(Portela & Ca.,SA)
参考来源:EP 1010688; GB 2344819; WO 0037423

NK-611

3-羟基-4H-吡喃-4-酮 3-羟甲基-1,2,3,4-四氢异喹啉 Chemical Name: 4-O-[2-Deoxy-2-(dimethylamino)-4:6-O-ethylidene-beta-D-glucopyranosyl]-4'-O-demethyl-1-epipodophyllotoxin; [5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-9-[[...
参考文献标题:4'-Demethyl-4-epipodophyllotoxin derivs.,a process for their preparation and their use as medicaments
文献作者:Umezawa,H.; Takeuchi,T.; Kondo,S.; Tanaka,W.; Takita,T.; Nishimura,Y.; Yoshikawa,H.(Microbial Chemistry Research Foundation)
参考来源:EP 0196618; ES 8706713; JP 1986227590; US 4716221

3-Deazauridine, NSC-126849, DAU

3-脱氮尿苷Chemical Name: 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
CAS No. 23205-42-7
项目整合开发状态: Biological Testing
项目研究机构: Sigma Chemical (Originator), Valeant (Originator)
合成路线:Treatment ...
参考文献标题:3-Deazauridine
文献作者:Chang,P.
参考来源:Drugs Fut 1984,9(10),739

Antineoplaston A10, NSC-648539

3-苯基乙酰氨基-2,6-哌啶二酮Chemical Name: (S)-N-(2,6-Dioxo-3-piperidinyl)benzeneacetamide; 3(S)-(N-Phenylacetylamino)-2,6-piperidinedione; (S)-N-Phenylacetyl-alpha-aminoglutarimide
CAS No. 91531-30-5
项目整合...
参考文献标题:Purified antineoplaston factions and methods of treating neoplastic disease
文献作者:Burzynski,S.R.(Burzynski Research Institute)
参考来源:EP 0069232; JP 5032548; JP 5058886; JP 58010521; US 4470970