项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

BMS-284640

Chemical Name: (1R,3R)-N-(Diaminomethylene)-3-(2,3-dihydro-1-benzofuran-4-yl)-2,2-dimethylcyclopropanecarboxamide
CAS No. 230640-88-7, 230640-89-8 (diastereomer), 312490-80-5 (hydrochloride), 31249...
参考文献标题:Acyl guanidine sodium/proton exchange inhibitors and method
文献作者:Wu,S.C.; Atwal,K.S.; Dugar,S.; Ahmad,S.(Bristol-Myers Squibb Co.)
参考来源:EP 1041980; JP 2001527042; US 6011059; WO 9933460

UCL-1608

Chemical Name: 1-[4-(9-Benzyl-9H-fluoren-9-yl)-2-butynyl]perhydroazepine oxalate
CAS No. 371172-31-5, 371172-30-4 (free base)
项目整合开发状态: Biological Testing
项目研究机构: University College London (O...
参考文献标题:Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca2+-activated K+ permeability of erythrocytes
文献作者:Roxburgh,C.J.; Ganellin,C.R.; Athmani,S.; Bisi,A.; Quaglia,W.; Benton,D.C.; Shiner,M.A.; Malik-Hall,M.; Haylett,D.G.; Jenkinson,D.H.
参考来源:J Med Chem 2001,44(20),3244

新产品编号:508331

Chemical Name: N,2-Bis[2-(dimethylamino)ethyl]-9-nitro-2,6-dihydropyrazolo[3,4,5-kl]acridine-5-carboxamide dihydrochloride
CAS No. 220249-88-7
项目整合开发状态: Biological Testing
项目研究机构: Universit?d...
参考文献标题:Pyrazolo-acridine derivs.having antitumour activity
文献作者:Matelli,S.; Polucci,P.; Antonini,I.(Universit?degli Studi di Camerino)
参考来源:WO 9906405

新产品编号:576357

Chemical Name: Erythromycin A (E)-9-[O-(3-phenoxypropyl)oxime]
CAS No. 227193-43-3
项目整合开发状态: Biological Testing
项目研究机构: Abbott (Originator)
合成路线:The title erythromycin O-(phenoxypropyl)oxi...
参考文献标题:Erythromycin derivs.
文献作者:Yoshida,T.; Kato,H.; Nishino,H.; Kado,N.; Nishimoto,A.(Hokuriku Seiyaku Co.,Ltd.)
参考来源:EP 1044985; JP 1999236395; WO 9929709

LY-508869

Chemical Name: 2,2,2-Trifluoro-N-[3-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide
CAS No. 353229-45-5, 353235-52-6 (hydrochloride)
项目整合开发状态: Biological Testing
项目研究机构: Lil...
参考文献标题:Potentiators of glutamate receptors
文献作者:Monn,J.A.; Hornback,W.J.; Schoepp,D.D.; Dressman,B.A.; Britton,T.C.; Tizzano,J.P.; Johnson,K.W.; Henry,S.S.; Coleman,D.S.; Jagdmann,G.E.J.; Johnson,M.P.; Large,T.H.; Barda,D.A.; Fichtner,M.W.(Eli Lilly and Company)
参考来源:WO 0156990

NCX-2111

Chemical Name: 2(S)-Acetamido-3-[2-(4-isobutylphenyl)propionylsulfanyl]propionic acid 4-(nitrooxy)butyl ester; N-Acetyl-S-[2-(4-isobutylphenyl)propionyl]-D-cysteine 4-(nitrooxy)butyl ester
CAS No. ...
参考文献标题:Pharmaceutical cpds.
文献作者:Del Soldato,P.(NicOx SA)
参考来源:EP 1169294; WO 0061537

NNC-895-9309, NNC-57-0541

Chemical Name: 1-[4-Amino-2-(phenylamino)thiazol-5-yl]-1-cyclopropylmethanone
CAS No. 223786-59-2
项目整合开发状态: Preclinical
项目研究机构: Agouron (Originator), Novo Nordisk (Originator)
合成路线:The rea...
参考文献标题:2,4-Diaminothiazole derivs.
文献作者:Olesen,P.H.; Kurtzhals,P.; Bowler,A.N.; Soerensen,A.R.; Worsaae,H.; Hansen,B.F.(Novo Nordisk A/S)
参考来源:WO 0156567

NNC-57-0588

Chemical Name: 1-[4-Amino-2-(propylamino)thiazol-5-yl]-1-(3-pyridyl)methanone
CAS No. 353512-12-6
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (Originator)
合成路线:The reaction of N1-amidino-N3...
参考文献标题:2,4-Diaminothiazole derivs.
文献作者:Olesen,P.H.; Kurtzhals,P.; Bowler,A.N.; Soerensen,A.R.; Worsaae,H.; Hansen,B.F.(Novo Nordisk A/S)
参考来源:WO 0156567

UCB-34743

Chemical Name: N-[4-[4-[2-[4-[1(R)-(4-Chlorophenyl)-1-phenylmethyl]piperazin-1-yl]ethoxy]phenyl]butyl]-N-hydroxyurea
CAS No. 299460-42-7
项目整合开发状态: Preclinical
项目研究机构: UCB Pharma (Originator)<...
参考文献标题:Cpds.and methods for treatment of asthma,allergy and inflammatory disorders
文献作者:Chatelain,P.; Differding,E.; Cai,X.; Hussoin,S.; Grewal,G.; Young,M.; Lewis,T.; Toy-Palmer,A.; Scannel,R.; Ellis,J.; Lassoie,M.-A.(UCB SA)
参考来源:JP 2002540198; US 6451801; WO 0058295

Orconazole nitrate, R-15556

Chemical Name: 1-[2-(4-Chlorophenyl)-2-(2,6-dichlorobenzyloxy)ethyl]-1H-imidazole nitrate
CAS No. 66778-38-9, 22833-02-9 (free base)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:Reaction of ...
参考文献标题:The preparation and properties of derivatives of 1-phenethyl imidazole
文献作者:Godefroi,E.F.; et al.
参考来源:J Med Chem 1969,12(5),784