项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

CDRI-93/478

Chemical Name: 1-[3-[4-(4-Fluorophenyl)piperazin-1-yl]propyl]pyrrolidin-2-one hydrochloride
CAS No. 223525-77-7 (free base)
项目整合开发状态: Preclinical
项目研究机构: Central Drug Research Institute (Orig...
参考文献标题:1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes and their use in medical treatments
文献作者:Jain,S.; Sinha,N.; Saxena,A.K.; Anand,N.; Saxena,R.M.; Dubey,M.P.; Patnaik,G.K.; Ray,M.(Council of Scientific and Industrial Research)
参考来源:US 6150367

CP-472555

Chemical Name: (4bS,7R,8aR)-4b-Benzyl-7-hydroxy-7-(1-propynyl)-N-(4-pyridinylmethyl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide
CAS No. 305821-96-9, 305825-01-8 (monohydrochloride)
项...
参考文献标题:Glucocorticoid receptor modulators
文献作者:Liu,K.K.-C.; Morgan,B.P.; Dow,R.L.; Swick,A.G.(Pfizer Inc.)
参考来源:EP 1175383; WO 0066522

LY-367265

Chemical Name: 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-4-yl]ethyl]-5,6-dihydro-1H,4H-[1,2,5]thiadiazolo[4,3,2-ij]quinoline 2,2-dioxide
CAS No. 210751-39-6, 210751-40-9 (phosphate...
参考文献标题:Substd.4-(6-fluoro-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridine for the treatment of CNS-disorders
文献作者:Fairhurst,J.(Eli Lilly and Company)
参考来源:EP 0854146; WO 9831686

AT-1362

Chemical Name: 4-[2(R)-[2(S)-[2-(6-Amidino-1-ethylindol-2-yl)ethyl]pyrrolidin-1-ylcarbonyl]pyrrolidin-1-yl]-2(S)-amino-4-oxobutyric acid
CAS No. 200183-43-3
项目整合开发状态: Preclinical
项目研究机构: C & ...
参考文献标题:Aromatic amidine derivs.useful as selective thrombin inhibitors
文献作者:Koo,B.A.; Min,J.K.; Hong,W.S.; Ryu,E.J.; Nam,W.H.; Kim,J.M.(C & C Research Laboratories)
参考来源:EP 0918768; JP 2000504030; US 6201006; WO 9745424

T-162559, T-559

Chemical Name: 2(E)-[7(S)-(5-Fluoro-2-methylphenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-ylidene]hydrazinecarboxamidine dimethanesulfonate
CAS No. 239132-64-0 (undefined isomer free base), 246874-...
参考文献标题:Aminoguanidine hydrazone derivs.,process for producing the same and drugs thereof
文献作者:Shiraishi,M.; Fukumoto,S.; Kusumoto,K.(Takeda Chemical Industries,Ltd.)
参考来源:EP 1057812; JP 2000191641; WO 9942442

BR-630

Chemical Name: 4-[2,3,4,5,6,7,8,9,10,11-Decamethyl-1,12-dicarba-closo-dodecaboran(12)-1-ylcarboxamido]benzoic acid
CAS No. 296782-99-5
项目整合开发状态: Biological Testing
项目研究机构: University of Tokyo...
参考文献标题:Polymethylcarborane as a novel biactive moiety: Derivatives with potent retinoid antagonistic activity
文献作者:Endo,Y.; Yaguchi,K.; Kawachi,E.; Kagechika,H.
参考来源:Bioorg Med Chem Lett 2000,10(15),1733

新产品编号:745631

Chemical Name: N-(tert-Butoxycarbonyl)-L-alanyl-N6-[3(S)-(2-methylpropyl)-4-oxooxetan-2(R)-ylcarbonyl]-N1-(1-naphthylmethyl)-L-lysinamide
CAS No. 284484-04-4
项目整合开发状态: Biological Testing
项目研究...
参考文献标题:Proteasome inhibitors
文献作者:Yamaguchi,H.; Kanda,Y.; Ikeda,S.; Akinaga,S.; Yamashita,Y.; Asai,A.; Mizukami,T.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 1166781; WO 0043000

SL-11093

Chemical Name: trans-N1-Ethyl-N4-[2-[4-(ethylamino)butylaminomethyl]cyclopropylmethyl]-1,4-butanediamine tetrahydrochloride; trans-1,2-Bis[4-(ethylamino)butylaminomethyl]cyclopropane tetrahydrochlorid...
参考文献标题:Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
文献作者:Marton,L.J.; Frydman,B.(SLIL Biomedical Corp.)
参考来源:WO 0066175

Calothrixin B

Chemical Name: 12,13-Dihydro-7H-indolo[3,2-j]phenanthridine-7,13-dione
CAS No. 254114-34-6
项目整合开发状态: Biological Testing
项目研究机构: Australian National University (Originator)
合成路线:N-Protectio...
参考文献标题:Synthesis of the potent antimalarials calothrixin A and B
文献作者:Kelly,T.R.; Zhao,Y.; Cavero,M.; Torneiro,M.
参考来源:Org Lett 2000,2(23),3735

Calothrixin A

Chemical Name: 12,13-Dihydro-7H-indolo[3,2-j]phenanthridine-7,13-dione 5-oxide
CAS No. 254114-33-5
项目整合开发状态: Biological Testing
项目研究机构: Australian National University (Originator)
合成路线:N-P...
参考文献标题:Synthesis of the potent antimalarials calothrixin A and B
文献作者:Kelly,T.R.; Zhao,Y.; Cavero,M.; Torneiro,M.
参考来源:Org Lett 2000,2(23),3735