项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

RXP-407

Chemical Name: 3(S)-Acetamido-4-[N-[1(R)-[[3-[1(S)-carbamoylethylamino]-2(S)-methyl-3-oxopropyl](hydroxy)phosphoryl]-2-phenylethyl]amino]-4-oxobutyric acid
CAS No. 237770-41-1, 237770-43-3 (diaster...
参考文献标题:N-Terminal site selective inhibitors of human angiotensin conversion enzyme (ACE)
文献作者:Yiotakis,A.; Menard,J.; Dive,V.; Michaud,A.; Ezan,E.; Corvol,P.; Cotton,J.; Chauvet,M.-T.; Cuniasse,P.(Commissariat a l'Energie Atomique; INSERM (Institut National de la Sante et de la Recherche Medicale))
参考来源:EP 1091966; WO 0001706

BIBM-1015CL, BIBM-1015

Chemical Name: 4-[1-Methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclopropyl]-1H-benzimidazol-2-ylmethylamino]benzamidine
CAS No. 253431-20-8, 253430-49-8 (HCl)
项目整合开发状态: Preclinical
项目研究机构: Boehring...
参考文献标题:Benzimidazoles,production thereof and use thereof as medicaments
文献作者:Kauffmann,I.; Ries,U.; Priepke,H.; Hauel,N.; Stassen,J.M.; Nar,H.; Wienen,W.(Boehringer Ingelheim Pharma KG)
参考来源:DE 19829964; EP 1095025; WO 0001704

L-756423

Chemical Name: 4-(2-Benzo[b]furanyl)-N-tert-butyl-1-[2(S)-hydroxy-4(R)-[N-[2(R)-hydroxyindan-1(S)-yl]carbamoyl]-5-phenylpentyl]piperazine-2(S)-carboxamide; 2(R)-Benzyl-5-[4-(2-benzo[b]furanyl)-2(S)-(N...
参考文献标题:Sulfate salt of an HIV protease inhibitor having an improved oral absorption and bioavailability
文献作者:Hoerrner,R.S.; Volante,R.P.; Purick,R.M.; Askin,D.; Reider,P.; Varsolona,R.J.(Merck & Co.,Inc.)
参考来源:EP 0986554; JP 2000513747; US 6071916; WO 9854178

DB-51630

Chemical Name: 3-(5-Nitro-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-2-yl)-N-[2-[2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-2-yl)ethylamino]ethyl]benzamide
CAS No. 254452-11-4
项...
参考文献标题:Naphthalimidobenzamide derivs.
文献作者:Suzuki,K.; Yamada,Y.; Asao,T.; Noguchi,K.; Wakida,M.(Taiho Pharmaceutical Co.,Ltd.)
参考来源:EP 1020446; US 6300331; WO 0001672

(3S,4S)-DHGA

Chemical Name: 2(S)-Amino-3(S),4(S)-dihydroxypentanedioic acid; 3(S),4(S)-Dihydroxy-L-glutamic acid
CAS No. 236751-52-3, 5115-47-9 (non-specified isomerism)
项目整合开发状态: Biological Testing
项目研究机...
参考文献标题:First enantiospecific synthesis of a 3,4-dihydroxy-L-glutamic acid[(3S,4S)-DHGA],a new mGluR1 agonist
文献作者:Dauban,P.; de Saint-Fuscien,C.; Acher,F.; Pr閦eau,L.; Brabet,I.; Pin,J.P.; Dodd,R.H.
参考来源:Bioorg Med Chem Lett 2000,10(2),129

新产品编号:558955

Chemical Name: N-Butyl-11-[3,17beta-dihydroxyestra-1,3,5(10)-trien-7alpha-ylsulfanyl]-N-methylundecanamide
CAS No. 223660-20-6
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)...
参考文献标题:Estra-1,3,5(10)-triene-7alpha-thioethers
文献作者:Jirkovsky,I.; Miller,C.P.; Tran,B.D.(American Home Products Corp.)
参考来源:EP 1025116; WO 9920646

新产品编号:653875

Chemical Name: (-)-2,6-Dimethyl-5-nitro-4(S)-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid 2-(nitrooxy)ethyl ester
CAS No. 250330-33-7, 250330-34-8 (enantiomer), 339528-66-4 (un...
参考文献标题:The design of (-)-(S)-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate: A cardioselective positive inotropic derivative of Bay K 8644
文献作者:Shan,R.; Knaus,E.E.
参考来源:Bioorg Med Chem Lett 1999,9(17),2613

Tamandarin A

Chemical Name: (3S,6S,10S,11R,14R,15R,18S,21S)-14-[N-[2(S)-Hydroxypropionyl]-L-prolyl-D-(N-methyl)leucylamino]-10-hydroxy-3-isobutyl-6-isopropyl-18-(4-methoxybenzyl)-15,19-dimethyl-11-[1(S)-methylprop...
参考文献标题:The first total synthesis of (-)-tamadarin A
文献作者:Liang,B.; Portonovo,P.; Vera,M.D.; Xiao,D.; Joullie,M.M.
参考来源:Org Lett 1999,1(8),1319

新产品编号:649129

Chemical Name: (?-N-[trans-4-(cis-1-allyl-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-ylaminomethyl)cyclohexylmethyl]benzenesulfonamide
CAS No. 247936-57-8
项目整合开发状态: Preclinical
项目研究机构: R.W. John...
参考文献标题:N-Substd.aminotetralins as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders
文献作者:Reitz,A.B.; Lovenberg,T.W.; Dax,S.L.; Youngman,M.A.; McNally,J.J.(Ortho-McNeil Pharmaceutical,Inc.)
参考来源:WO 9955667

RPR-118031A

Chemical Name: (+)-2(S)-[5-(1,3-Benzodioxol-5-ylmethoxy)-2-cyanophenoxy]-2-(2-methylphenyl)acetic acid sodium salt
CAS No. 181038-67-5 (free acid)
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma...
参考文献标题:Substd.phenyl cpds.as endothelin antagonists
文献作者:Porter,B.; Astles,P.C.; Bridge,A.W.; McLay,I.M.; Van Sickle,A.P.; Walsh,R.J.A.; McCarthy,C.; Morley,A.D.; Halley,F.; Harris,N.V.; Majid,T.N.; Smith,C.(Rh鬾e-Poulenc Rorer Ltd.)
参考来源:US 6048893; US 6124343; WO 9622978