项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

SB-235375

Chemical Name: 2-[2-Phenyl-4-[N-[1(S)-phenylpropyl]carbamoyl]quinolin-3-yloxy]acetic acid
CAS No. 224961-34-6, 192704-51-1 (monoHCl), 224633-16-3 (monosodium salt)
项目整合开发状态: Preclinical
项目研究机...
参考文献标题:Quinoline derivs.
文献作者:Giardina,G.A.M.; Grugni,M.; Raveglia,L.F.; Farino,C.(GlaxoSmithKline plc)
参考来源:EP 0876347; JP 2000501104; US 6277862; WO 9721680

PMS-847, S-22068

Chemical Name: 2-(4,5-Dihydro-1H-imidazol-2-yl)-1,4-diisopropylpiperazine
CAS No. 162510-35-2
项目整合开发状态: Preclinical
项目研究机构: Servier (Originator)
合成路线:Alkylation of ethyl piperazine-2-carbo...
参考文献标题:Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes.2.Syntheses and biological activities of 1,4-dialkyl-,1,4-dibenzyl,and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines an
文献作者:Le Bihan,G.; Rondu,F.; Pele-Tounian,A.; Wang,X.; Lidy,S.; Touboul,E.; Lamouri,A.; Dive,G.; Huet,J.; Pfeiffer,B.; Renard,P.; Guardiola-Lemaitre,B.; Manechez,D.; Penicaud,L.; Ktorza,A.; Godfroid,J.J.
参考来源:J Med Chem 1999,42(9),1587

RO-28-2653

Chemical Name: 5-(4-Biphenylyl)-5-[4-(4-nitrophenyl)piperazin-1-yl]barbituric acid; 5-(4-Biphenylyl)-5-[4-(4-nitrophenyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
CAS No. 261956-22-3
项目整合...
参考文献标题:New barbituric acid derivs.,processes for their production and pharmaceutical agents containing these cpds.
文献作者:Bosies,E.; Esswein,A.; Grams,F.; Krell,H.-W.; Menta,E.(Roche Diagnostics GmbH)
参考来源:DE 19548624; EP 0869947; JP 2000505069; US 6110924; US 6472396; WO 9723465

SB-239063

Chemical Name: trans-4-[4-(4-Fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazol-1-yl]cyclohexanol; trans-4-(4-Fluorophenyl)-1-(4-hydroxycyclohexyl)-5-(2-methoxypyrimidin-4-yl)imidazole
CAS No. 19355...
参考文献标题:Novel cycloalkyl substd.imidazoles
文献作者:Adams,J.L.; Garigipati,R.S.(SmithKline Beecham plc)
参考来源:EP 0883402; WO 9725047

BIIB-513

Chemical Name: N2-[4-[4-(2-Furylcarbonyl)piperazin-1-yl]-3-(methylsulfonyl)benzoyl]guanidine methanesulfonate
CAS No. 193401-08-0 (mono HCl salt)
项目整合开发状态: Preclinical
项目研究机构: Boehringer Inge...
参考文献标题:Novel benzoyl guanidine derivs.,process for their preparation and their use in the preparation of medicines
文献作者:B黵ger,E.; Eickmeier,C.; Roos,O.(Boehringer Ingelheim GmbH)
参考来源:DE 19601303; EP 0882031; JP 2000503309; US 6114335; WO 9726253

TX-525

Chemical Name: 17alpha-Acetoxy-6alpha-methyl-19-nor-1beta,2beta-dihydrocyclopropa[1,2]pregn-4-ene-3,20-dione
CAS No. 193087-98-8
项目整合开发状态: Preclinical
项目研究机构: Th閞amex (Originator)
合成路线:The...
参考文献标题:New 19-nor-pregnene derivs.
文献作者:Piasco,A.; Lafay,J.; Delansorne,R.; Paris,J.; Pascal,J.-C.(Laboratoire Th閞amex)
参考来源:JP 2000503980; WO 9727210

新产品编号:252047

Chemical Name: 3-Benzyl-8-methyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one
CAS No. 193217-46-8
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:The compound is prepare...
参考文献标题:Chromeno[3,4-c]pyridin-5-ones: Selective human dopamine D4 receptor antagonists as potential antipsychotic agents
文献作者:Unangst,P.C.; Capiris,T.; Connor,D.T.; Heffner,T.G.; MacKenzie,R.G.; Miller,S.R.; Pugsley,T.A.; Wise,L.D.
参考来源:J Med Chem 1997,40(17),2688

YM-75466, YM-466(free base), YM-60828(free base)

Chemical Name: 2-[N-(7-Amidinonaphthalen-2-ylmethyl)-N-[4-[1-(1-iminoethyl)piperidin-4-yloxy]phenyl]sulfamoyl]acetic acid methanesulfonate
CAS No. 201933-41-7 (free base)
项目整合开发状态: Phase I
项目...
参考文献标题:Novel amidinonaphthyl derivs.or salt thereof
文献作者:Hirayama,F.; Koshio,H.; Matsumoto,Y.; Kawasaki,T.; Kaku,S.; Yanagisawa,I.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:EP 0798295; US 5869501; WO 9616940

L-775606

Chemical Name: 1-[2-(3-Fluorophenyl)ethyl]-4-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperazine
CAS No. 188400-51-3
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Originator)
合成路线:Alky...
参考文献标题:3-(Piperazinylpropyl)indoles: Selective,orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents
文献作者:Chambers,M.S.; Street,L.J.; Goodacre,S.; Hobbs,S.C.; Hunt,P.; Jelley,R.A.; Matassa,V.G.; Reeve,A.J.; Sternfeld,F.; Beer,M.S.; Stanton,J.A.; Rathbone,D.; Watt,A.P.; MacLeod,A.M.
参考来源:J Med Chem 1999,42(4),691

PKF-217-744, SDZ-217-744

Chemical Name: (+)-(3S,4R)-N-[3-Hydroxy-2,2-dimethyl-6-(2-methyl-4-pyridyl)-3,4-dihydro-2H-1-benzopyran-4-yl]pyridine-3-carboxamide
CAS No. 184876-45-7 (trans-isomer)
项目整合开发状态: Preclinical
项目...
参考文献标题:2,2-Dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans,their use as pharmaceuticals
文献作者:Manley,P.W.(Novartis AG; Novartis Deutschland GmbH)
参考来源:EP 0623129; WO 9412493