Chlorozotocin CAS Registry Number: 54749-90-5 氯脲霉素
CAS Name: 2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-D-glucose
Additional Names: 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose; 1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea; DCNUPercent Composition: C 34.46%, H 5.14%, Cl 11.30%, N 13.40%, O 35.70%
📌 参考资料/链接：
Literature References: Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, lomustine, nimustine, ranimustine, q.q.v; 2-chloroethyl analog of streptozotocin, q.v. Synthesis: H. D. Burns et al., Org. Prep. Proced. Int. 6, 259 (1974); T. P. Johnston et al., J. Med. Chem. 18, 104 (1975). Pharmacology: T. Anderson et al., Cancer Res. 35, 761 (1975); P. S. Schein et al., Cancer Treat. Rep. 60, 801 (1976). Decomposition in aqueous media: J. A. Montgomery et al., J. Med. Chem. 18, 568 (1975).
📄 详细内容
Properties: Ivory colored crystals, mp 147-148° (dec with the evolution of gas), (Burns, Heindel). Also reported as mp 140-141° (dec), (Johnston). Sol in water.
Melting point: mp 147-148° (dec with the evolution of gas); mp 140-141° (dec)
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-62.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrosoureas.
产品链接: 54749-90-5››