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Voacamine CAS Registry Number: 3371-85-5 老刺木胺

CAS Name: 12-Methoxy-13-[(3a)-17-methoxy-17-oxovobasan-3-yl]ibogamine-18-carboxylic acid methyl ester
Additional Names: voacanginine
Percent Composition: C 73.27%, H 7.44%, N 7.95%, O 11.35%

📌 参考资料/链接：
Literature References: Bisindole alkaloid found in Voacanga africana Stapf., V. thouarsii R. Sch., var obtusa (K. Sch.) Pichon and V. schweinfurthii Staph., Apocynaceae: Janot, Goutarel, Compt. Rend. 240, 1719 (1955); Rao, J. Org. Chem. 23, 1455 (1958); Janot, Goutarel, US 2823204 (1958 to Lab. Gobey). Identity with voacanginine: LeBarre, Gillo, Bull. Acad. R. Med. Belg. 20, 194 (1956). Cleaved by acid catalysis to voacangine: Winkler, Naturwissenschaften 48, 694 (1961). Structure: Goutarel et al., Compt. Rend. 243, 1670 (1956); Percheron, Ann. Chim. (Paris) 4, 303 (1959); Büchi et al., J. Am. Chem. Soc. 85, 1893 (1963). Review: Gorman et al. in The Alkaloids 1, J. E. Saxton, Ed. (The Chem. Soc., London, 1971) pp 242-249.

📄 详细内容

Properties: Prisms from acetone + methanol, dec 223°. [a]D20 -52° (chloroform). uv max: 225, 295 nm (log e 4.72, 4.28). Sol in chloroform, acetone; slightly sol in methanol, ethanol.
Optical Rotation: [a]D20 -52° (chloroform)
Absorption maximum: uv max: 225, 295 nm (log e 4.72, 4.28)
Derivative Type: Voacangine
Additional Names: Carbomethoxyibogaine; 12-methoxyibogamine-18-carboxylic acid methyl ester
Percent Composition: C 71.71%, H 7.66%, N 7.60%, O 13.03%
Literature References: Structure: Bartlett et al., J. Am. Chem. Soc.
80, 126 (1958).
Properties: Prismatic needles from ethanol, mp 136-137°. Sublimes0.01 135°. [a]D20 -42° (c = 1.26 in chloroform). pKa 7.4 (40% aq methanol); pKa 5.73 (33% DMF). uv max (methanol): 225, 287 300 nm (log e 4.43, 3.97, 3.93). Freely sol in acetone, chloroform; slightly sol in methanol, ethanol.
Melting point: mp 136-137°
pKa: pKa 7.4 (40% aq methanol); pKa 5.73 (33% DMF)
Optical Rotation: [a]D20 -42° (c = 1.26 in chloroform)
Absorption maximum: uv max (methanol): 225, 287 300 nm (log e 4.43, 3.97, 3.93)
产品链接: 3371-85-5››

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