网站主页>>>项目整合精选>>>项目整合精选>>>Pyrrolnitrin CAS Registry Number: 1018-71-9 硝吡咯菌素

Pyrrolnitrin CAS Registry Number: 1018-71-9 硝吡咯菌素

CAS Name: 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole
Additional Names: 3-chloro-4-(2'-nitro-3'-chlorophenyl)pyrrole; PN
Trademarks: Pyroace (Fujisawa)
Percent Composition: C 46.72%, H 2.35%, Cl 27.58%, N 10.90%, O 12.45%

📌 参考资料/链接：
Literature References: Antifungal antibiotic isolated from Pseudomonas pyrrocinia n. sp.: K. Arima et al., Agric. Biol. Chem. 28, 575 (1964); eidem, J. Antibiot. 18, 201 (1965). Structure: Imanaka et al., ibid. 207. Synthesis: S. Umio et al., BE 670427; eidem, US 3428648 (1964, 1969 both to Fujisawa); Nakano et al., Tetrahedron Lett. 1966, 737; S. Umio et al. (10 publications) Chem. Pharm. Bull. 17, 559-628 (1969); Gosteli, Helv. Chim. Acta 55, 451 (1972). Pharmacological studies: M. Nishida et al., J. Antibiot. 18, 211 (1965).

📄 详细内容

Properties: Pale yellow crystals from hot cyclohexane, mp 124.5°. Gradually changes to a red or brown color on exposure to sunlight and loses antibiotic activity. uv max: 252 nm (e 7500). Slightly sol in water, petr ether, cyclohexane; sol in methanol, ethanol, butanol, acetone, ethyl acetate, benzene, ether, chloroform, carbon tetrachloride, pyridine, acetic acid. LD50 in rats, rabbits (mg/kg): 68, 105 i.p. (Nishida).
Melting point: mp 124.5°
Absorption maximum: uv max: 252 nm (e 7500)
Toxicity data: LD50 in rats, rabbits (mg/kg): 68, 105 i.p. (Nishida)
Therap-Cat: Antifungal.
Keywords: Antifungal (Antibiotics).
产品链接: 1018-71-9››

← 返回产品列表