Safinamide CAS Registry Number: 133865-89-1 沙芬酰胺

📌 参考资料/链接：
Literature References: Voltage-dependent sodium and calcium channel blocker; selective and reversible inhibitor of monoamine oxidase B (MAO-B). Prepn: P. Dostert et al., EP 400495; eidem, US 5236957 (1990, 1993 both to Farmitalia); and anticonvulsant activity: P. Pevarello et al., J. Med. Chem. 41, 579 (1998). Mechanism of action study: P. Salvati et al., J. Pharmacol. Exp. Ther. 288, 1151 (1999). Review of early clinical development: P. L. Chazot, Curr. Opin. Invest. Drugs 2, 809-813 (2001). Clinical pharmacokinetics and pharmacodynamics: A. Marzo et al., Pharmacol. Res. 50, 77 (2004). Clinical evaluation in Parkinson's disease: F. Stocchi et al., Neurology 63, 746 (2004).