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Alazopeptin CAS Registry Number: 1397-84-8 丙氨肽霉素

Additional Names: L-Alanyl-(6-diazo-5-oxo)-L-norleucyl-(6-diazo-5-oxo)-L-norleucine
Percent Composition: C 49.45%, H 5.53%, N 23.07%, O 21.96%

📌 参考资料/链接：
Literature References: Tumor-inhibiting antibiotic produced by Streptomyces griseoplanus from soil near Williamsburg, Iowa: De Voe et al., Antibiot. Annu. 1956-7, p 730. Peptide consisting of one mole a-alanine and two moles of a C6 diazo keto amino acid oxidizable to glutamic acid: E. L. Patterson et al., Antimicrob. Agents Chemother. 1965, 115-118. Anti-tumor activity: T. Hata et al., J. Antibiot. 26, 181 (1973). Toxicity: J. B. Thiersch, Proc. Soc. Exp. Biol. Med. 97, 888 (1958).

📄 详细内容

Derivative Type: Monohydrate
Properties: Crystals from dilute acetone. Poor stability. Has no definite melting point. [a]D25 +9.5° (c = 4.7 in H2O). uv max (pH 7.0 phosphate buffer): 242, 274 nm (E1%1cm 321, 549). Freely sol in water. Somewhat sol in acetic acid, formamide, DMSO, aq solns of methanol, ethanol, acetone. Practically insol in anhydr alcohols, acetone, ethyl acetate, ether. LD50 i.p. in rats: 150 mg/kg (Thiersch).
Optical Rotation: [a]D25 +9.5° (c = 4.7 in H2O)
Absorption maximum: uv max (pH 7.0 phosphate buffer): 242, 274 nm (E1%1cm 321, 549)
Toxicity data: LD50 i.p. in rats: 150 mg/kg (Thiersch)
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