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Tixocortol CAS Registry Number: 61951-99-3 替可的松

CAS Name: (11b)-11,17-Dihydroxy-21-mercaptopregn-4-ene-3,20-dione
Additional Names: 11b,17a-dihydroxy-21-thio-3,20-dioxo-4-pregnene
Percent Composition: C 66.63%, H 7.99%, O 16.91%, S 8.47%

📌 参考资料/链接：
Literature References: Synthesis and biological activity: S. S. Simons et al., J. Steroid Biochem. 13, 311 (1980). Use in fluorescent chemoaffinity labeling: eidem, Biochemistry 18, 4915 (1979). Prepn of the 21-pivalate: D. R. Torossian et al., DE 2357778; eidem, US 4014909 (1974, 1977 both to Jouveinal). Series of articles on pharmacology, in vitro and in vivo activity of the pivalate: Arzneim.-Forsch. 31, 453-469 (1981).

📄 详细内容

Properties: Fine white solid, dec 220-221°. uv max (95% ethanol): 241 nm (e 1.65´104).
Absorption maximum: uv max (95% ethanol): 241 nm (e 1.65´104)
Derivative Type: 21-Pivalate
CAS Registry Number: 55560-96-8
CAS Name: (11b)-21-[(2,2-Dimethyl-1-oxopropyl)thio]-11,17-dihydroxypregn-4-ene-3,20-dioneTrademarks: Pivalone (Jouveinal); Rectovalone (Jouveinal); Tiovalon (Intersan)
Percent Composition: C 67.50%, H 8.28%, O 17.29%, S 6.93%
Properties: Crystals from ethanol, mp 195-200°. [a]D20 +145° (c = 1 in dioxane). uv max (methanol): 229 nm (log e 4.259).
Melting point: mp 195-200°
Optical Rotation: [a]D20 +145° (c = 1 in dioxane)
Absorption maximum: uv max (methanol): 229 nm (log e 4.259)
Use: Free thiol in chemoaffinity labeling.
Therap-Cat: Anti-inflammatory.
Keywords: Glucocorticoid.
产品链接: 61951-99-3››

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