网站主页>>>项目整合精选>>>项目整合精选>>>Cefminox CAS Registry Number: 84305-41-9 5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸,7-[[2-[[(2S)-2-氨基-2-羧乙基]硫代]氨基]-7-甲氧基-3-[[(1-甲基-1H-四唑-5-基)硫代]甲基]-8-氧基-,(6R,7S)-

Cefminox CAS Registry Number: 84305-41-9 5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸,7-[[2-[[(2S)-2-氨基-2-羧乙基]硫代]氨基]-7-甲氧基-3-[[(1-甲基-1H-四唑-5-基)硫代]甲基]-8-氧基-,(6R,7S)-

CAS Name: (6R,7S)-7-[[[[(2S)-2-Amino-2-carboxyethyl]thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 7b-(2-D-amino-2-carboxyethylthioacetamido)-7a-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid
Percent Composition: C 36.99%, H 4.07%, N 18.87%, O 21.56%, S 18.51%

📌 参考资料/链接：
Literature References: Semisynthetic broad spectrum cephamycin antibiotic. Prepn: BE 880656, K. Iwamatsu et al., US 4357331 (1980, 1982 both to Meiji Seika). Synthesis, biological activity: eidem, J. Antibiot. 36, 229 (1983). Structure-activity studies: S. Inouye et al., ibid. 37, 1403 (1984). Proposed mechanism of action: T. Tsuruoka et al., Eur. J. Biochem. 151, 209 (1985). In vitro, in vivo antibacterial activity compared with that of other cephalosporins: S. Inouye et al., Antimicrob. Agents Chemother. 26, 722 (1984). Activity against gram-negative infections in mice: T. Watanabe et al., Drugs Exp. Clin. Res. 10, 293 (1984). Toxicity studies: M. Kurebe et al., Jpn. J. Antibiot. 37, 847 (1984). Series of articles on pharmacokinetics, early clinical trials, treatment of urinary tract and respiratory infections: Chemotherapy (Tokyo) 32, Suppl. 5 (1984) 561 pp.

📄 详细内容

Derivative Type: Sodium salt heptahydrate Trademarks: Meicelin (Meiji Seika)
Percent Composition: C 28.78%, H 5.13%, N 14.69%, Na 3.44%, O 33.55%, S 14.41%
Properties: Crystals from ethanol-water, mp 90-91°. LD50 in male, female mice (mg/kg): 6100, 5200 i.v.; in male, female rats (mg/kg): 6600, 5700 i.v.; 8600, 8550 i.p.; 15000, 15000 s.c. or orally (Kurebe).
Melting point: mp 90-91°
Toxicity data: LD50 in male, female mice (mg/kg): 6100, 5200 i.v.; in male, female rats (mg/kg): 6600, 5700 i.v.; 8600, 8550 i.p.; 15000, 15000 s.c. or orally (Kurebe)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephamycins.
产品链接: 84305-41-9››

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