其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Pipacycline CAS Registry Number: 1110-80-1 匹哌环素

CAS Name: [4S-(4a,4aa,5aa,6b,12aa)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-2-naphthacenecarbox...
Literature References: Semi-synthetic broad spectrum antibiotic related to tetracycline. Prepn: Pedrazzoli et al., Boll. Chim. Farm. 98, 516 (1959), C.A. 54, 3856a (1960); Gradnik et al., GB 888968 corresp to US 3149114 (1962 and 1964 to E.R.A.S.M.E.). Properties: eidem, Pharm. Acta Helv. 35, 529 (1960). Pharmacokinetic studies: A. Scalvini, A. Delmonte, Gazz. Med. Ital. 131, 1 (1972).

Cefminox CAS Registry Number: 84305-41-9 5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸,7-[[2-[[(2S)-2-氨基-2-羧乙基]硫代]氨基]-7-甲氧基-3-[[(1-甲基-1H-四唑-5-基)硫代]甲基]-8-氧基-,(6R,7S)-

CAS Name: (6R,7S)-7-[[[[(2S)-2-Amino-2-carboxyethyl]thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Addition...
Literature References: Semisynthetic broad spectrum cephamycin antibiotic. Prepn: BE 880656, K. Iwamatsu et al., US 4357331 (1980, 1982 both to Meiji Seika). Synthesis, biological activity: eidem, J. Antibiot. 36, 229 (1983). Structure-activity studies: S. Inouye et al., ibid. 37, 1403 (1984). Proposed mechanism of action: T. Tsuruoka et al., Eur. J. Biochem. 151, 209 (1985). In vitro, in vivo antibacterial activity compared with that of other cephalosporins: S. Inouye et al., Antimicrob. Agents Chemother. 26, 722 (1984). Activity against gram-negative infections in mice: T. Watanabe et al., Drugs Exp. Clin. Res. 10, 293 (1984). Toxicity studies: M. Kurebe et al., Jpn. J. Antibiot. 37, 847 (1984). Series of articles on pharmacokinetics, early clinical trials, treatment of urinary tract and respiratory infections: Chemotherapy (Tokyo) 32, Suppl. 5 (1984) 561 pp.

Rubitecan CAS Registry Number: 91421-42-0 9-硝基喜树碱

CAS Name: (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Additional Names: 9-nitrocamptothecin; 9-nitro-(20S)-camptothecin; 9-NC
Trademarks...
Literature References: Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin, (9-AC), q.v. Prepn: JP Kokai 59 51288 (1984 to Yakult Honsha), C.A. 101, 91322 (1984); M. C. Wani et al., J. Med. Chem. 29, 2358 (1986); and activity: S. Sawada et al., Chem. Pharm. Bull. 39, 3183 (1991). Conversion to 9-AC by human cells: P. Pantazis et al., Eur. J. Haematol. 53, 246 (1994); eidem, ibid. 55, 211 (1995). Clinical trial in pancreatic cancer: J. S. Stehlin et al., Int. J. Oncol. 14, 821 (1999). Review: C. F. Verschraegen, Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs 1, 184-190 (1999).

Cefaclor CAS Registry Number: 70356-03-5 头孢克洛

CAS Name: (6R,7R)-7-[[(2R)-Aminophenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate
Additional Names: 7-(D-2-amino-2-phenylacetamido)-3-chloro-3...
Literature References: Semi-synthetic cephalosporin antibiotic, related to cephalexin, q.v. Prepn: R. R. Chauvette, DE 2408698 (1974 to Lilly), C.A. 82, 4278n (1975); US 3925372 (1975 to Lilly); R. R. Chauvette, P. A. Pennington, J. Med. Chem. 18, 403 (1975). In vitro studies: M. S. Silver et al., Antimicrob. Agents Chemother. 12, 591 (1977); R. N. Jones, J. Antibiot. 30, 753 (1977); B. R. Meyers, S. Z. Hirschman, J. Clin. Pharmacol. 18, 85 (1978). Metabolism: N. G. Waterman, L. F. Sharfenberger, Antimicrob. Agents Chemother. 14, 614 (1978). Human pharmacology: G. R. Hodges et al., ibid. 454; A. Glynne et al., J. Antimicrob. Chemother. 4, 343 (1978). Clinical studies: J. D. Nelson et al., Am. J. Dis. Child. 132, 992 (1978); B. M. Gray et al., Antimicrob. Agents Chemother. 13, 988 (1978). Comprehensive description: L. J. Lorenz, Anal. Profiles Drug Subs. 9, 107-123 (1980).

Cephaloglycin CAS Registry Number: 3577-01-3 头孢来星

CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2R)-aminophenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 7-(2-amino-2-phenylacetamido)-3-(hydroxym...
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: BE 635137; F. W. Wall et al., US 3422103 (1964, 1969 both to Glaxo); GB 1017624 (1966 to Merck Co.); Spencer et al., J. Med. Chem. 9, 746 (1966); of D- and DL-forms: GB 985747 (1965 to Lilly); Kurita et al., J. Antibiot. 19A, 243 (1966). Metabolism and pharmacokinetics in man: J. Haginaka et al., J. Antibiot. 33, 236 (1980).

Cephaloridine CAS Registry Number: 50-59-9 头孢噻啶

CAS Name: 1-[[(6R,7R)-2-Carboxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt
Additional Names: 1-[(7'-b-[2-(2-thienyl)acetamido]-8'-oxo-...
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: FR 1384197 (1965 to Glaxo), C.A. 63, 11591c (1965); E. H. Flynn, US 3449338 (1969 to Lilly). Toxicity studies: Atkinson et al., Toxicol. Appl. Pharmacol. 8, 398 (1966).

Cephacetrile Sodium CAS Registry Number: 23239-41-0 头孢乙腈钠

CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-7-[(cyanoacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt
Additional Names: sodium 7-(2-cyanoacetamido)-3-(hydro...
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: NL 6600586; Bickel et al., US 3483197 (1966, 1969 both to Ciba). Activity studies: Knüsel et al., Antimicrob. Agents Chemother. 1970, 140; Neu et al., J. Antibiot. 25, 400 (1972). Pharmacokinetics and clinical results: Kradolfer et al., Schweiz. Med. Wochenschr. 103, 711 (1973); Riess et al., ibid. 718. Toxicology: Kradolfer et al., Antimicrob. Agents Chemother. 1970, 150. Review: Arzneim.-Forsch. 24, 1446-1533 (1974).

Cefadroxil CAS Registry Number: 66592-87-8 头孢羟氨苄

CAS Name: (6R,7R)-7-[[(2R)-Amino-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate
Additional Names: 7-[D-(-)-a-amino-a-(4-hydroxyp...
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: NL 6812382; L. B. Crast, Jr., US 3489752 (1969, 1970 both to Bristol-Myers); T. Takahashi et al., DE 2216113; eidem, US 3816253 (1972, 1974, both to Takeda). Prepn of crystalline monohydrate: D. Bouzard et al., US 4504657 (1985 to Bristol-Myers). Antimicrobial activity: R. E. Buck, K. E. Price, Antimicrob. Agents Chemother. 11, 324 (1977). Pharmacology: M. Pfeffer et al., ibid. 331; A. I. Hartstein et al., ibid. 12, 93 (1977). Review: J. Antimicrob. Chemother. 10, Suppl. B, 1-162 (1982). Series of articles on clinical trials in respiratory tract infections: Drugs 32, Suppl. 3, 1-56 (1986).

Cephalothin CAS Registry Number: 153-61-7 头孢噻吩酸

CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamid...
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: Chauvette et al., J. Am. Chem. Soc. 84, 3401 (1962); E. H. Flynn, US 3218318 (1965 to Lilly); FR 1384197 (1965 to Glaxo), C.A. 63, 11591c (1965). Bacteriology and pharmacology: Lee, Anderson, Antimicrob. Agents Chemother. 1962, 695; Walters et al., ibid. 706; Naumann, Arzneim.-Forsch. 16, 1099 (1966). Acute toxicity: M. Kuramoto et al., Jpn. J. Antibiot. 27, 746 (1974), C.A. 83, 71972t (1975). Comprehensive description: R. J. Simmons, Anal. Profiles Drug Subs. 1, 319-341 (1972).

Cephalexin CAS Registry Number: 15686-71-2 头孢氨苄

CAS Name: (6R,7R)-7-[[(2R)-Aminophenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 7-(D-a-aminophenylacetamido)desacetoxycephalosporanic ...
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: R. B. Morin, B. G. Jackson, US 3275626; US 3507861 (1966, 1970 both to Lilly); Ryan et al., J. Med. Chem. 12, 310 (1969). Pharmacology and toxicology: Muggleton et al., Antimicrob. Agents Chemother. 1968, 353; Kind et al., Welles et al., ibid. 361, 489. Comprehensive description: L. P. Marrelli, Anal. Profiles Drug Subs. 4, 21-46 (1975). Clinical pharmacology, efficacy, adverse reactions: Postgrad. Med. J. 59, Suppl. 5, 1-56 (1983).