Gaboxadol CAS Registry Number: 64603-91-4 盐酸加波沙朵(THIP 盐酸盐)

📌 参考资料/链接：
Literature References: Selective extrasynaptic GABA agonist (SEGA); structural analog of muscimol, q.v. Prepn: P. Krogsgaard-Larsen, Acta Chem. Scand. B 31, 584 (1977); idem, EP 167; idem, US 4278676 (1979, 1981 both to H. Lundbeck Co.). GABA agonist effects: idem et al., Nature 268, 53 (1977). 3H-THIP binding study: E. Falch, P. Krogsgaard-Larsen, J. Neurochem. 38, 1123 (1982). HPLC determn: S. M. Madsen, J. Chromatogr. 238, 509 (1982). Pharmacokinetics: idem et al., Acta Pharmacol. Toxicol. 53, 353 (1983). Pharmacodynamics and potential therapeutic uses: A. V. Christensen et al., Pharm. Weekbl. Sci. Ed. 4, 145 (1982). Clinical effects on nocturnal sleep and hormone secretion: M. Lancel et al., Am. J. Physiol. Endocrinol. Metab. 281, E130 (2001); on night sleep and cognitive performance: S. Mathias et al., Neuropsychopharmacology 30, 833 (2005). Review of clinical development: R. Huckle, Curr. Opin. Invest. Drugs 5, 766-773 (2004).