Properties: Stout prisms from chloroform + methanol, dec 285° (rapid heating). [a]20546 +3.5° (c = 1.02 in pyridine). Absorption max (98% H2SO4): 315, 415, 495, 530 nm (E1%1cm 275, 185, 430, 505). Almost insol in chloroform, ethyl acetate and acetone. Dissolves in a mixture of chloroform and alcohol or in pyridine or in dil alcohol. Less sol in hot 80% alcohol than digoxin.
Optical Rotation: [a]20546 +3.5° (c = 1.02 in pyridine)
Absorption maximum: Absorption max (98% H2SO4): 315, 415, 495, 530 nm (E1%1cm 275, 185, 430, 505)
Derivative Type: a- and b-Acetylgitoxin
Percent Composition: C 62.75%, H 8.08%, O 29.16%
Properties: Obtained by enzymatic hydrolysis of digilanide B. b-Form: Long, thin, hair-like prisms from dil methanol, dec 220-225°. [a]D20 +15.7° (c = 1.28 in pyridine). Sol in 80-100 parts methanol; sparingly sol in water and ether.
Optical Rotation: [a]D20 +15.7° (c = 1.28 in pyridine)
Derivative Type: Pentaacetate
CAS Registry Number: 7242-04-8
Additional Names: Pengitoxin; penta-O-acetylgitoxin
Trademarks: Carnacid-Cor (TAD); Cordoval (Tempelhof); Pentagit (Berlin-Chemie)
Percent Composition: C 61.80%, H 7.53%, O 30.67%
Literature References: Mass spectral studies: Blessington, Morton, Org. Mass Spectrom.
3, 95 (1970).
Properties: Rhomboid crystals, mp 151-155°. [a]D20 +14.0 ±1.5° (c = 1.6 in pyridine). LD50 in mice (mg/kg): 6.4 i.p.; in rats (mg/kg): 21.0 i.v. (Foerster).
Melting point: mp 151-155°
Optical Rotation: [a]D20 +14.0 ±1.5° (c = 1.6 in pyridine)
Toxicity data: LD50 in mice (mg/kg): 6.4 i.p.; in rats (mg/kg): 21.0 i.v. (Foerster)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.
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