Exametazime CAS Registry Number: 105613-48-7 依沙美肟

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Literature References: Propyleneamine oxime derivative that forms a neutral, lipophilic complex with 99mTc which diffuses across cellular membranes, including the blood brain barrier. Used in regional cerebral blood flow imaging. Prepn: L. R. Canning et al., EP 194843; eidem, US 4789736 (1986, 1988 both to Amersham). Prepn and ra-diopharmacology of 99mTc complex: D. P. Nowotnik et al., Nucl. Med. Commun. 6, 499 (1985); R. D. Neirinckx et al., J. Nucl. Med. 28, 191 (1987). Clinical comparison of isomers: P. F. Sharp et al., ibid. 27, 171 (1986). Biodistribution in humans: K. Nakamura et al., Eur. J. Nucl. Med. 15, 100 (1989). Clinical evaluation in single photon emission tomography (SPECT) of meningiomas: S. Nakano et al., J. Nucl. Med. 30, 1101 (1989). 99mTc radiolabeling of human platelets: H. J. Danpure, S. Osman, Nucl. Med. Commun. 9, 267 (1988); of human leukocytes: H. J. Danpure et al., ibid. 465. Clinical study of labeled leukocytes for imaging inflammatory lesions: J. H. Reynolds, Clin. Radiol. 42, 195 (1990). Series of articles on basic and clinical studies: J. Cereb. Blood Flow Metab. 8, S1-S126 (1988).