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项目整合精选>>>Nidulin CAS Registry Number: 10089-10-8 6-[(2E)-2-丁烯-2-基]-2,4,7-三氯-3-羟基-8-甲氧基-1,9-二甲基-11H-二苯并[b,e][1,4]二氧杂卓-11-酮
Nidulin CAS Registry Number: 10089-10-8 6-[(2E)-2-丁烯-2-基]-2,4,7-三氯-3-羟基-8-甲氧基-1,9-二甲基-11H-二苯并[b,e][1,4]二氧杂卓-11-酮
CAS Name: (E)-2,4,7-Trichloro-3-hydroxy-8-methoxy-1,9-dimethyl-6-(1-methyl-1-propenyl)-11H-dibenzo[b,e][1,4]dioxepin-11-one
Additional Names: methylustin; ustin methyl ether
Percent Composition: C 54.14%, H 3.86%, Cl 23.97%, O 18.03%
📌 参考资料/链接：
Literature References: Antibiotic substance produced by a strain of Aspergillus nidulans (Eidam) Wint.: Dean et al., Nature 172, 344 (1953); Dean et al., J. Chem. Soc. 1954, 1432. Structure: Dean et al., ibid. 1960, 4829; Bycroft et al., ibid. 1963, 5148.
📄 详细内容
Properties: Slender, shiny rods from petr ether, mp 180°. Practically insol in water. Sol in aq solns of sodium hydroxide and sodium bicarbonate. Freely sol in chloroform. Sparingly sol in 95% ethanol and in benzene. Very sparingly sol in hot petr ether. A 4% soln in chloroform shows no optical activity. Completely inhibits in vitro the growth of Mycobacterium tuberculosis for four weeks at a diln of between 1 in 5000 and 1 in 10,000 when tested in the presence of serum by modified Long's medium and the floating-pellicle method. A 0.1% soln also inhibits the growth of the human parasitic fungi Trichophyton tonsurans and Microsporum audouini, but shows little or no activity towards a wide range of other microorganisms. Inactive against bacteriophage.
Melting point: mp 180°
Status: This monograph has been retired and is no longer subject to revision or update.
产品链接: 10089-10-8››