Toyocamycin CAS Registry Number: 606-58-6 丰加霉素
CAS Name: 4-Amino-7-b-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Additional Names: 4-amino-5-cyano-7-(D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; uramycin B; vengicide; antibiotic 1037Percent Composition: C 49.48%, H 4.50%, N 24.05%, O 21.97%
📌 参考资料/链接：
Literature References: Antibiotic substance extracted from the culture filtrate and mycelium of Streptomyces toyocaensis. Isoln: Nishimura et al., J. Antibiot. 9A, 60 (1956). Structure: Ohkuma, ibid. 14A, 343 (1961). Synthesis of aglycone: Taylor, Hendess, J. Am. Chem. Soc. 86, 951 (1964). Total synthesis: Tolman et al., ibid. 90, 524 (1968); 91, 2102 (1969). Biosynthesis: Uematsu, Suhadolnik, Biochemistry 9, 1260 (1970); eidem, J. Biol. Chem. 245, 4365 (1970). Crystal and molecular structure: P. Prusiner, M. Sundaralingam, Acta Crystallogr. B34, 517 (1978).
📄 详细内容
Properties: Fine needles from methanol or acetone, mp 243°. Recrystallization from water yields the hydrate, C12H13N5O4.H2O, mp 239-243°. [a]D16 -45.7° (c = 1.05 in 0.1N HCl). uv max (H2O): 230, 277 nm (E1%1cm 400, 548). Soluble in acetic acid, acidic solns. Moderately sol in methanol, ethanol, acetone, dioxane, butanol, water, ether. Practically insol in chloroform, ethyl acetate, petr ether. LD100 s.c. in mice: 10-20 mg/kg (Nishimura).
Melting point: mp 243°; mp 239-243°
Optical Rotation: [a]D16 -45.7° (c = 1.05 in 0.1N HCl)
Absorption maximum: uv max (H2O): 230, 277 nm (E1%1cm 400, 548)
Toxicity data: LD100 s.c. in mice: 10-20 mg/kg (Nishimura)
产品链接: 606-58-6››