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Fervenulin CAS Registry Number: 483-57-8 热诚菌素

CAS Name: 6,8-Dimethylpyrimido[5,4-e]-1,2,4-triazine-5,7-(6H,8H)-dione
Additional Names: 6,8-dimethyl-5,7-dioxo-5,6,7,8-tetrahydropyrimido[5,4-e]-as-triazine; 1,3-dimethylazalumazine; planomycin
Percent Composition: C 43.53%, H 3.65%, N 36.26%, O 16.57%

📌 参考资料/链接：
Literature References: Antibiotic from culture filtrates of Streptomyces fervens: Eble et al., Antibiot. Annu. 1959-1960, 227. Structure: Daves et al., J. Org. Chem. 26, 5256 (1961). Synthesis: Pfleiderer, Schündehütte, Ann. 615, 42 (1958); Daves et al., J. Am. Chem. Soc. 84, 1724 (1962); Yoneda, Nagamatsu, Bull. Chem. Soc. Jpn. 48, 2884 (1975); Taylor, Sowinski, J. Org. Chem. 40, 2321 (1975); S. Senda et al., J. Am. Chem. Soc. 99, 7358 (1977).

📄 详细内容

Properties: Yellow orthorhombic crystals, mp 178-179°. uv max (ethanol): 238, 275, 340 nm (e 18,500, 1600, 4200). Sol in practically all of the common organic solvents; sol in cold water to about 2 mg/ml; in hot water to about 40 mg/ml. Practically insol in hydrocarbons. Labile to alkali; stable to acid.
Melting point: mp 178-179°
Absorption maximum: uv max (ethanol): 238, 275, 340 nm (e 18,500, 1600, 4200)
Derivative Type: 4-Oxide
Percent Composition: C 40.20%, H 3.37%, N 33.48%, O 22.95%
Literature References: Synthesis: M. Ichiba et al., J. Heterocycl. Chem.
14, 175 (1977); K. Senga et al., Heterocycles
6, 273 (1977); synthesis and conversion to fervenulin: M. Ichiba et al., J. Org. Chem.
43, 469 (1978).
Properties: Crystals from alc, mp 179-180°. uv max (alc): 240, 304 nm (log e 4.10, 3.21).
Melting point: mp 179-180°
Absorption maximum: uv max (alc): 240, 304 nm (log e 4.10, 3.21)
产品链接: 483-57-8››

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