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Doxapram CAS Registry Number: 309-29-5 多沙普仑

CAS Name: 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone
Percent Composition: C 76.16%, H 7.99%, N 7.40%, O 8.45%

📌 参考资料/链接：
Literature References: Prepn: C. D. Lunsford, A. D. Cale, BE 613734; eidem, US 3192206 (1962, 1965 both to A. H. Robins); Lunsford et al., J. Med. Chem. 7, 302 (1964). Clinical comparison with mepixanox in chronic bronchopulmonary disease: M. Parziale et al., G. Ital. Mal. Torace 38, 323 (1984). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

📄 详细内容

Derivative Type: Hydrochloride monohydrate
CAS Registry Number: 7081-53-0Trademarks: Dopram (Robins); Doxapril (Erba); Stimulexin (Robins)
Percent Composition: C 66.58%, H 7.68%, N 6.47%, O 11.09%, Cl 8.19%
Properties: Crystals from isopropyl ether, mp 217-219°. Bitter taste. Sol in water; sparingly sol in alc, slightly sol in chloroform. LD50 orally in rats: 261 mg/kg (Goldenthal).
Melting point: mp 217-219°
Toxicity data: LD50 orally in rats: 261 mg/kg (Goldenthal)
Derivative Type: Benzoate
Percent Composition: C 74.37%, H 7.25%, N 5.60%, O 12.78%
Properties: Crystals, mp 123-124°.
Melting point: mp 123-124°
Therap-Cat: Respiratory stimulant.
Therap-Cat-Vet: Respiratory stimulant.
Keywords: Respiratory Stimulant.
产品链接: 309-29-5››

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