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Avoparcin CAS Registry Number: 37332-99-3 阿伏帕星

Trademarks: Avotan (Roche)
📌 参考资料/链接：
Literature References: Animal feed glycopeptide antibiotic complex produced by Streptomyces candidus. Prodn: M. P. Kunstmann, J. N. Porter, US 3338786 (1967 to Am. Cyanamid). Fermentation, isoln, characterization: M. P. Kunstmann et al., Antimicrob. Agents Chemother. 8, 242 (1968). Isoln, purif of major components: W. J. McGahren et al., J. Antibiot. 36, 1671 (1983). HPLC separation of a-, b-avoparcin: F. Sztaricskai et al., ibid. 1691. Structural studies: J. J. Hlavka et al., Tetrahedron Lett. 1974, 175; W. J. McGahren et al., J. Am. Chem. Soc. 101, 2237 (1979). Structure: eidem, ibid. 102, 1671 (1980). Stereochemistry and epimerization: G. A. Ellestad et al., J. Antibiot. 36, 1683 (1983). Relationship between structure, antibacterial activity: S.W. Fesik et al., Mol. Pharmacol. 25, 275 (1984). Effect on resistance patterns in chickens: J. R. Walton, Zentralbl. Veterinaermed. (B) 25, 290 (1978), C.A. 89, 173507 (1978). Prevention of exptly induced necrotic enteritis in chickens: J. F. Prescott, Avian Dis. 23, 1072 (1979). Effect on feedlot performance: R. J. Johnson et al., J. Anim. Sci. 48, 1338 (1979).

📄 详细内容


Properties: White, hygroscopic, amorphous solid; no definitive mp. uv max: 280 nm in neutral or acidic solns; 300 nm in basic solns. Sol in water, DMF, DMSO. Max stability of aq solns is at pH 4-8. Moderately sol in methanol. LD50 in mice, rats, and chickens: 10000 mg/kg orally (Am. Cyanamid, company literature).
Absorption maximum: uv max: 280 nm in neutral or acidic solns; 300 nm in basic solns
Toxicity data: LD50 in mice, rats, and chickens: 10000 mg/kg orally (Am. Cyanamid, company literature)
Derivative Type: a-Avoparcin
CAS Registry Number: 73957-86-5
Percent Composition: C 55.99%, H 5.38%, Cl 1.86%, N 6.60%, O 30.17%
Properties: [a]D25 -96 ±2° (c = 0.62 in 0.1N HCl). uv max (0.1N HCl): 280 nm (E1%1cm 42.0).
Optical Rotation: [a]D25 -96 ±2° (c = 0.62 in 0.1N HCl)
Absorption maximum: uv max (0.1N HCl): 280 nm (E1%1cm 42.0)
Derivative Type: b-Avoparcin
CAS Registry Number: 73957-87-6
Percent Composition: C 55.00%, H 5.24%, Cl 3.65%, N 6.49%, O 29.63%
Properties: [a]D25 -102 ±2° (c = 0.65 in 0.1N HCl). uv max (0.1N HCl): 280 nm (E1%1cm 44.0).
Optical Rotation: [a]D25 -102 ±2° (c = 0.65 in 0.1N HCl)
Absorption maximum: uv max (0.1N HCl): 280 nm (E1%1cm 44.0)
Therap-Cat-Vet: Antibacterial; growth promotant.
产品链接: 37332-99-3››
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