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Hydroquinine CAS Registry Number: 522-66-7 氢化奎宁

CAS Name: (8a,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol
Additional Names: dihydroquinine
Percent Composition: C 73.59%, H 8.03%, N 8.58%, O 9.80%

📌 参考资料/链接：
Literature References: An alkaloid of cinchona, found in quinine sulfate mother liquors. Stereoisomeric with hydroquinidine, q.v. Usually prepd by careful hydrogenation of quinine: Heidelberger, Jacobs, J. Am. Chem. Soc. 41, 819 (1919). Total synthesis: Rabe et al., Ber. 64B, 2487 (1931). Synthesis of isomers: Rubtsov, J. Gen. Chem. USSR 9, 1493 (1939), C.A. 34, 2850 (1940); ibid. 13, 593, 702 (1943), C.A. 39, 705 (1945). LC determn in quinine beverages: L. P. Valenti, J. Assoc. Off. Anal. Chem. 68, 782 (1985).

📄 详细内容

Properties: Needles from ether or benzene, mp 172°. [a]D18 -142° (alc); [a]D20 -236° (c = 0.82 in 0.1N H2SO4). pK1 = 5.33. Freely sol in acetone, alcohol, chloroform, ether, petr ether; fairly sol in ammonia water. Almost insol in water (290 mg/l).
Melting point: mp 172°
pKa: pK1 = 5.33
Optical Rotation: [a]D18 -142° (alc); [a]D20 -236° (c = 0.82 in 0.1N H2SO4)
Derivative Type: Hydrochloride hemihydrate
Percent Composition: C 64.59%, H 7.59%, Cl 9.53%, N 7.53%, O 10.76%
Properties: Prisms from water, mp 208° (Heidelberger). [a]D21 -124° (c = 1.1). pH of 0.005 molar soln 5.85. Freely sol in water, alcohol, methanol, acetone. Almost insol in ether. Crystallizes also with 2 mols H2O. Infrared spectrum: J. Suszko, Z. Dega-Szafran, Bull. Acad. Pol. Sci. Ser. Sci. Chim.
12, 607 (1964), C.A.
62, 7819b (1965).
Melting point: mp 208° (Heidelberger)
Optical Rotation: [a]D21 -124° (c = 1.1)
Therap-Cat: Depigmentor.
Keywords: Depigmentor.
产品链接: 522-66-7››

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