Properties: Red needles from acetone, mp 120-130°; also reported as mp 149° (dec) (Sigg, Toth). Strongly exothermic at 149°. May explode on drying with heat: Rachlin, Chem. Eng. News
45, 32 (Sept. 4, 1967). uv max (0.1 N HCl): 283, 340 nm (e 97000, 5400); absorption max (0.1N HCl): 505 nm (e 6500). Stable in water after 6 hours at 37° in 0.05N acetate buffer at pH 5.0, in 0.05N phosphate at pH 6.0 and 7.0, or in 0.005N tris-HCl at pH 8.0 and 9.0. Stable at 70° except in phosphate buffer. Acetate, methanol, or aq tris buffer solns remain stable indefinitely at 4°. LD50 in mice (mg/kg): 2000 orally, 2000 s.c., 133 i.p. (Grunberg).
Melting point: mp 120-130°; mp 149° (dec) (Sigg, Toth)
Absorption maximum: uv max (0.1 N HCl): 283, 340 nm (e 97000, 5400); absorption max (0.1N HCl): 505 nm (e 6500)
Toxicity data: LD50 in mice (mg/kg): 2000 orally, 2000 s.c., 133 i.p. (Grunberg)
Derivative Type: Copper(II) complex
CAS Registry Number: 39238-36-3
Additional Names: CuprimyxinTrademarks: UNITOP (Roche)
Percent Composition: C 54.03%, H 3.14%, Cu 10.99%, N 9.69%, O 22.14%
Literature References: Prepn: W. Leimgruber et al.,
DE
1931466; eidem,
US
3586674 (1970, 1971 both to Hoffmann-La Roche). Activity studies: Maestrone et al., Am. J. Vet. Res.
33, 185 (1972).
Properties: Dark green, fine crystals. uv max (DMSO): 287, 300, 356 nm (e 68500, 63200, 10000); absorption max (DMSO): 408, 610 nm (e 10400, 9500).
Absorption maximum: uv max (DMSO): 287, 300, 356 nm (e 68500, 63200, 10000); absorption max (DMSO): 408, 610 nm (e 10400, 9500)
Therap-Cat-Vet: Antibacterial, antifungal.
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