Properties: White to off-white crystalline, odorless powder. pKa1 (25°) 2.5; pKa2 4.0; pKa3 6.7; pKa4 10.1. Approx uv max (0.1N NaOH): 246, 254, 258, 261, 267 nm (A1%1cm 4.0, 4.5, 5.1, 5.1, 3.7); (0.1N HCl): 246, 253, 258, 264, 267 nm (A1%1cm 3.2, 3.9, 4.5, 3.0, 2.8). [a]25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); [a]25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate). Partition coefficient at room temp (n-octanol/0.1M pH 7 phosphate buffer): 10.2 ±0.5. Soly (mg/ml): water 97; methanol 14; ethanol <0.1; acetone <0.1; acetonitrile <0.1; chloroform <0.1; DMF <0.1.
pKa: pKa1 (25°) 2.5; pKa2 4.0; pKa3 6.7; pKa4 10.1
Optical Rotation: [a]25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); [a]25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)
Log P: Partition coefficient at room temp (n-octanol/0.1M pH 7 phosphate buffer): 10.2 ±0.5
Absorption maximum: uv max (0.1N NaOH): 246, 254, 258, 261, 267 nm (A1%1cm 4.0, 4.5, 5.1, 5.1, 3.7)
Derivative Type: Mixture with hydrochlorothiazide
Trademarks: Prinzide (Merck Co.); Zestoretic (AstraZeneca)
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.
产品链接: 83915-83-7››