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Bethanidine CAS Registry Number: 55-73-2 倍他尼定

CAS Name: N,N'-Dimethyl-N''-(phenylmethyl)guanidine
Additional Names: 1-benzyl-2,3-dimethylguanidine; N-benzyl-N',N''-dimethylguanidine
Percent Composition: C 67.76%, H 8.53%, N 23.71%

📌 参考资料/链接：
Literature References: Adrenergic neuron blocking agent. Prepn: Walton, Ruffell, US 3168562 (1965 to Wellcome Found.); GB 1084461 and GB 1111564 (1967 and 1968 to Wellcome Found.). Pharmacology: A. L. A. Boura, A. F. Green, Br. J. Pharmacol. 20, 36 (1963); J. A. Oates et al., Ann. N.Y. Acad. Sci. 179, 302 (1971). Pharmacokinetics: C. N. Corder, J. Clin. Pharmacol. 19, 428 (1979). HPLC determn in plasma: J. R. Shipe et al., Clin. Chem. 29, 1793 (1983). Anti-arrhythmic activity: M. B. Bacaner, D. G. Benditt, Am. J. Cardiol. 50, 728 (1982); J. C. Somberg et al., ibid. 54, 343 (1984). Review: A. F. Green, Br. J. Clin. Pharmacol. 13, 25-34 (1982).

📄 详细内容

Properties: Crystals from methanol + ether, mp 195-197°.
Melting point: mp 195-197°
Derivative Type: Hydriodide
Percent Composition: C 39.36%, H 5.28%, N 13.77%, I 41.59%
Properties: Crystals from ethanol + ether, mp 141-146°.
Melting point: mp 141-146°
Derivative Type: Sulfate
CAS Registry Number: 114-85-2
Additional Names: BenzaidinTrademarks: Bendogen (Lagap); Benzoxine (Sanwa); Betaling (Tanabe); Betanidol (Tanabe Seiyaku); Esbatal (Burroughs Wellcome); Eusmanid; Hypersin (Zeria); Tenathan (Robins)
Percent Composition: C 53.08%, H 7.13%, N 18.57%, S 7.09%, O 14.14%
Properties: LD50 in mice (mg/kg): 12 i.v.; 150 i.p.; 260 s.c.; 520 by stomach intubation (Boura, Green).
Toxicity data: LD50 in mice (mg/kg): 12 i.v.; 150 i.p.; 260 s.c.; 520 by stomach intubation (Boura, Green)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Guanidine Derivatives.
产品链接: 55-73-2››

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