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Narceine CAS Registry Number: 131-28-2 那碎因[鹼]

CAS Name: 6-[[6-[2-(Dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid
Additional Names: 6-[[6-[2-(dimethylamino)ethyl]-2-methoxy-3,4-(methylenedioxy)phenyl]acetyl]-o-veratric acid
Percent Composition: C 62.01%, H 6.11%, N 3.14%, O 28.73%

📌 参考资料/链接：
Literature References: Occurs in opium to the extent of 0.1-0.5%. The separation from morphine mother liquors is tedious: Merck, Chem. Ztg. 13, 525 (1889). Prepn from narcotine or gnoscopine: Roser, Ann. 247, 167 (1888); Frankforter, Keller, Ann. Chem. J. 22, 61 (1899); Frerichs, Arch. Pharm. 241, 259 (1903); Hope, Robinson, J. Chem. Soc. 105, 2100 (1914). Structure: Freund, Frankforter, Ann. 277, 20 (1893); Freund, Michaels, Ann. 286, 248 (1895); Freund, Ber. 40, 194 (1907); Freund, Oppenheim, Ber. 42, 1084 (1909); Addinall, Major, J. Am. Chem. Soc. 55, 1202, 2153 (1933).

📄 详细内容

Properties: The anhydr material is very hygroscopic, mp 138°. uv max (ethanol): 270 nm (log e 3.98). Usually the alkaloid is obtained as the trihydrate. Clusters of silky, prismatic needles from water, mp 176°. pKb (20°) = 10.7, pKa = 9.3. pH of satd soln = 5.8. One gram dissolves in 770 ml water, 220 ml boiling water. Moderately sol in hot alcohol, nearly insol in benzene, chloroform, ether, petr ether; sol in alkali hydroxide solns forming salts, also in dil mineral acids.
Melting point: mp 138°; mp 176°
pKa: pKb (20°) = 10.7, pKa = 9.3
Absorption maximum: uv max (ethanol): 270 nm (log e 3.98)
Derivative Type: Ethylnarceine hydrochloride
Additional Names: Narcyl
Percent Composition: C 58.88%, H 6.32%, Cl 6.95%, N 2.75%, O 25.10%
Properties: Plates from water, mp 208-210°. Slightly sol in cold water, sol in hot water, alcohol, chloroform; insol in ether.
Melting point: mp 208-210°
Therap-Cat: Ethylnarceine hydrochloride as analgesic (narcotic); antitussive.
Keywords: Analgesic (Narcotic); Antitussive.
产品链接: 131-28-2››

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