Clevudine CAS Registry Number: 163252-36-6 克拉夫定

📌 参考资料/链接：
Literature References: Nucleoside analog; specific inhibitor of viral DNA synthesis. Prepn: C. K. Chu et al., WO 9520595; eidem, US 5587362 (1995, 1996 both to Univ. Georgia Res. Found.; Yale Univ.); T. Ma et al., J. Med. Chem. 39, 2835 (1996). Synthesis: M. L. Sznaidman et al., Nucleosides Nucleotides Nucleic Acids 21, 155 (2002). In vitro antiviral activity: C. K. Chu et al., Antimicrob. Agents Chemother. 39, 979 (1995). Pharmacokinetics: J. D. Wright et al., Pharm. Res. 12, 1350 (1995). Mechanism of action study: Y. Chong, C. K. Chu, Bioorg. Med. Chem. Lett. 12, 3459 (2002). Clinical evaluation in chronic hepatitis B: P. Marcellin et al., Hepatology 40, 140 (2004). Review of preclinical pharmacology: C. K. Chu et al. in Therapies for Viral Hepatitis, R. F. Schinazi et al., Eds. (Int. Med. Press, London, 1998) pp 303-312; of development and clinical experience: G. R. Painter et al. in Frontiers in Viral Hepatitis, R. F. Schinazi et al., Eds. (Elsevier, New York, 2003) pp 281-300.