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Bopindolol CAS Registry Number: 62658-63-3 波吲洛尔

CAS Name: 1-[(1,1-Dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol benzoate ester
Additional Names: (±)-1-(tert-butylamino)-3-[(2-methylindol-4-yl)oxy]-2-propanol benzoate (ester)
Percent Composition: C 72.60%, H 7.42%, N 7.36%, O 12.62%

📌 参考资料/链接：
Literature References: Nonselective b-adrenergic blocker. Prepn: F. Troxler, F. Seemann, DE 2635209; eidem, US 4340541 (1977, 1982 both to Sandoz). Clinical pharmacology: P. van Brummelen et al., Eur. J. Clin. Pharmacol. 22, 491 (1982). HPLC determn in plasma: C. J. Oddie et al., J. Chromatogr. 273, 469 (1983). Effect on plasma lipid fractions: P. van Brummelen et al., Br. J. Clin. Pharmacol. 17, 86 (1984). Pharmacokinetics: R. Platzer et al., Clin. Pharmacol. Ther. 36, 5 (1984). Clinical trials in hypertension: U. L. Hulthen et al., J. Cardiovasc. Pharmacol. 5, 426 (1983); W. J. Schiess et al., Eur. J. Clin. Pharmacol. 27, 529 (1984).

📄 详细内容

Properties: Sol in ether, methylene chloride. LD50 i.v. in mice: 17 mg/kg (Troxler, Seemann, 1977).
Toxicity data: LD50 i.v. in mice: 17 mg/kg (Troxler, Seemann, 1977)
Derivative Type: Maleate
CAS Registry Number: 62658-64-4
Trademarks: Sandonorm (Novartis)
Percent Composition: C 65.31%, H 6.50%, N 5.64%, O 22.55%
Derivative Type: Malonate
CAS Registry Number: 82857-38-3Trademarks: Wandonorm (Novartis)
Percent Composition: C 64.45%, H 6.66%, N 5.78%, O 23.11%
Therap-Cat: Antihypertensive.
Keywords: ?Adrenergic Blocker; Antihypertensive; Aryloxypropanolamine Derivatives.
产品链接: 62658-63-3››

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