Acrivastine CAS Registry Number: 87848-99-5 阿伐斯汀
CAS Name: (2E)-3-[6-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid
Additional Names: (E)-6-[(E)-3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-2-pyridineacrylic acidTrademarks: Semprex (GSK)
Percent Composition: C 75.83%, H 6.94%, N 8.04%, O 9.18%
📌 参考资料/链接：
Literature References: Nonsedating type histamine H1-receptor antagonist; analog of triprolidine, q.v. Prepn: G. G. Coker, J. W. A. Findlay, EP 85959 (1983 to Wellcome); J. W. A. Findlay, G. G. Coker, US 4501893 (1985). Pharmacodynamics and pharmacokinetics in humans: A. F. Cohen et al., Eur. J. Clin. Pharmacol. 28, 197 (1985). Evaluation of CNS effects: A. F. Cohen et al., Clin. Pharmacol. Ther. 38, 381 (1985). Clinical trials in idiopathic urticaria: J. G. Gibson et al., Dermatologica 169, 179 (1984); H. Neittaanmaki et al., ibid. 177, 98 (1988); in allergic rhinitis: T. G. Gibbs et al., J. Int. Med. Res. 16, 413 (1988). Review of pharmacology and therapeutic efficacy: R. N. Brogden, D. McTavish, Drugs 41, 927-940 (1991).
📄 详细内容
Properties: Crystals from isopropanol, mp 222° (dec).
Melting point: mp 222° (dec)
NOTE: Combination with pseudoephedrine,
Duact (Glaxo Wellcome) .
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Alkylamine Derivatives.
产品链接: 87848-99-5››