Tebanicline CAS Registry Number: 198283-73-7 替巴克兰

📌 参考资料/链接：
Literature References: Non-opioid 3-pyridyl ether analgesic acting acting via a neuronal nicotinic acetylcholine receptor mediated mechanism. Prepn: M. W. Holladay et al., WO 9640682; M. A. Abreo et al., US 5948793 (1996, 1999 both to Abbott); as hydrochloride: M. W. Holladay et al., J. Med. Chem. 41, 407 (1998). Asymmetric synthesis: J. K. Lynch et al., Tetrahedron: Asymmetry 9, 2791 (1998). Analgesic activity and receptor affinity: A. W. Bannon et al., Science 279, 77 (1998). Pharmacology in vitro: D. L. Donnelly-Roberts et al., J. Pharmacol. Exp. Ther. 285, 777 (1998); in vivo: A. W. Bannon et al., ibid. 787. Efficacy in neuropathic pain models: idem et al., Brain Res. 801, 158 (1998).