Foscarnet Sodium CAS Registry Number: 63585-09-1 膦甲酸钠

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Literature References: Inhibits viral DNA polymerase and reverse transcriptase. Prepn: P. Nylén, Ber. 57B, 1023 (1924). Crystal structure: R. R. Naqvi et al., J. Chem. Soc. A 1971, 2751; S. C. Abrahams, Acta Crystallogr. B28, 2886 (1972). Use as antiviral agent: B. F. H. Eriksson et al., DE 2728685; eidem, US 4215113 (1978, 1980 both to Astra). Activity against herpes simplex virus: E. Helgstrand et al., Science 201, 819 (1978); J. M. Reno et al., Antimicrob. Agents Chemother. 13, 188 (1978); S. Alenius et al., Arch. Virol. 60, 197 (1979). Mechanism of inhibition of Epstein-Barr virus replication: A. K. Datta, R. E. Hood, Virology 114, 52 (1981). Preclinical evaluation: B. Oeberg et al., Int. Congr. Ser. - Excerpta Med. 571, 175 (1982). Inhibitory effect on HIV-1 (HTLV-III/LAV) virus replication in vitro: P. S. Sarin et al., Biochem. Pharmacol. 34, 4075 (1985).