Candicidin CAS Registry Number: 1403-17-4 杀念菌素

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Literature References: Heptaene macrolide antifungal antibiotic complex composed of candicidins A, B, C and D (major component). Produced by a strain of Streptomyces griseus (Rutgers no. 3570): Lechevalier et al., Mycologia 45, 155 (1953). Methods of isoln: Siminoff, US 2872373 (1959 to Penick); Waksman, Lechevalier, US 2992162 (1961 to Rutgers Res. Ed. Found.). Activity: Kligman, Lewis, Proc. Soc. Exp. Biol. Med. 82, 399 (1953); Lancet 1, 507 (1954); Lechevalier, Presse Med. 61, 1327 (1953). Structure of candicidin D: J. Zielinski et al., Tetrahedron Lett. 1979, 1791. Biosynthesis studies: Liu et al., J. Antibiot. 25, 116 (1972). Anticholesteremic property and mode of action studies: I. H. Kwon, H. Fisher, Nutr. Rep. Int. 9, 245 (1974); A. K. Singhal et al., Lipids 16, 423 (1981). HPLC comparison of candicidin, hamycin, trichomycin, q.q.v.: P. Helboe et al., J. Chromatogr. 189, 249 (1980). Toxicity study: L. C. Vining et al., Antibiot. Annu. 1954-55, 980.