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Cabergoline CAS Registry Number: 81409-90-7 卡麦角林

CAS Name: (8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
Additional Names: 1-ethyl-3-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'b-carbonyl)urea; 1-[(6-allylergoline-8b-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylureaTrademarks: Dostinex (Pharmacia Upjohn)
Percent Composition: C 69.15%, H 8.26%, N 15.51%, O 7.09%

📌 参考资料/链接：
Literature References: Dopamine D2-receptor agonist. Prepn: P. Salvati et al., BE 888243; eidem, US 4526892 (1981, 1985 both to Farmitalia Carlo Erba). Prepn and bioactivity: E. Brambilla et al., Eur. J. Med. Chem. 24, 421 (1989). Clinical pharmacology: C. Ferrari et al., J. Clin. Endocrinol. Metab. 63, 941 (1986). Veterinary trial as abortifacient in dogs: K. Post et al., Theriogenology 29, 1233 (1988). Clinical evaluation to prevent puerperal lactation: G. B. Melis et al., Obstet. Gynecol. 71, 311 (1988); in hyperprolactinemic disorders: C. Ferrari et al., J. Clin. Endocrinol. Metab. 68, 1201 (1989). Clinical trial in Parkinson's disease: J. T. Hutton et al., Neurology 46, 1062 (1996).

📄 详细内容

Properties: White crystals from diethyl ether, mp 102-104°. Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: 400 mg/kg (Brambilla).
Melting point: mp 102-104°
Toxicity data: Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: 400 mg/kg (Brambilla)
Derivative Type: Diphosphate
CAS Registry Number: 85329-89-1
Percent Composition: C 48.22%, H 6.69%, N 10.81%, O 24.71%, P 9.57%
Properties: mp 153-155°.
Melting point: mp 153-155°
Therap-Cat: Prolactin inhibitor; antiparkinsonian.
Therap-Cat-Vet: Prolactin inhibitor.
Keywords: Antiparkinsonian; Dopamine Receptor Agonist; Prolactin Inhibitor.
产品链接: 81409-90-7››

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