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Cysteine CAS Registry Number: 52-90-4 L-半胱氨酸


CAS Name: L-Cysteine
Additional Names: Cys; C; b-mercaptoalanine; (R)-2-amino-3-mercaptopropanoic acid; 2-amino-3-mercaptopropionic acid; a-amino-b-thiolpropionic acid; half-cystine; thioserine
Percent Composition: C 29.74%, H 5.82%, N 11.56%, O 26.41%, S 26.47%
📌 参考资料/链接:
Literature References: A non-essential amino acid in human development. Readily oxides to form a dimeric amino acid, cystine, q.v., in which the two Cys are linked via a disulfide bridge, a common structural feature in proteins. Early chemistry and biochemistry: Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) 950 pp., passim; J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vol 1-3 (John Wiley and Sons, Inc., New York, 1961) pp. 1879-1928, passim. Simple synthesis of racemic cysteine: V. J. Martens et al., Angew. Chem. Int. Ed. 20, 668 (1981). Determn in proteins: J. G. Hoogerheide, C. M. Campbell, Anal. Biochem. 201, 146 (1992); D. Atherton et al., ibid. 212, 98 (1993). Review of biosynthesis: N. M. Kredich et al., Ciba Found. Symp. (Netherlands) 72, 87-99 (1980). Review of transport in mammalian cells: S. Bannai, Biochim. Biophys. Acta 779, 289-306 (1984). Review of effects on acrylonitrile toxicity: D. E. Nerland et al., Drug Metab. Rev. 20, 233-246 (1989). Review of thermodynamics and kinetics: T. R. Ralph et al., J. Electroanal. Chem. 375, 1-15 (1994); of electrosynthesis: eidem, ibid. 17-27. Review of role in chemo- and radioprotectant strategies: J. C. Roberts, Amino Acids 8, 113-124 (1995).

📄 详细内容


Properties: Crystals. [a]D25 +6.5° (5N HCl); [a]D25 +13.0° (glacial acetic acid). pK1 1.71; pK2 8.33; pK3 10.78. Absorption spectrum: Abderhalden, Rossner, Z. Physiol. Chem.
178, 160 (1928). Freely sol in water, alcohol, acetic acid, ammonia water. Insol in ether, acetone, ethyl acetate, benzene, carbon disulfide, carbon tetrachloride. In neutral or slightly alkaline aq solns it is oxidized to cystine by air. More stable in acidic solns.
pKa: pK1 1.71; pK2 8.33; pK3 10.78
Optical Rotation: [a]D25 +6.5° (5N HCl); [a]D25 +13.0° (glacial acetic acid)
Derivative Type: Hydrochloride
CAS Registry Number: 52-89-1
Percent Composition: C 22.86%, H 5.12%, N 8.89%, O 20.30%, S 20.34%, Cl 22.49%
Properties: Crystals, dec 175-178°. [a]D25 +5.0° (5N HCl); [a]D25 +10.0° (glacial acetic acid). Sol in water, alcohol, acetone; the aq soln is acid. Keep tightly closed. Decomposes and oxidizes slowly; hygroscopic.
Optical Rotation: [a]D25 +5.0° (5N HCl); [a]D25 +10.0° (glacial acetic acid)
Use: As dough conditioner.
Therap-Cat-Vet: Has been used as a detoxicant.
产品链接: 52-90-4››