Oxaceprol CAS Registry Number: 33996-33-7 N-乙酰基-L-羟脯氨酸

📌 参考资料/链接：
Literature References: Derivative of hydroxyproline having anti-inflammatory activity. Prepn: R. L. M. Synge, Biochem. J. 33, 1924 (1939); J. J. Kolb, G. Toennies, J. Biol. Chem. 144, 193 (1942); O. Leonardo et al., DE 2301358 corresp to US 3860607 (1973, 1975 to Richardson-Merrell). Elucidation of cyclic conformation and cis/trans isomerism about the amide bond: T. Prange et al., Biochem. Biophys. Res. Commun. 61, 104 (1974). Crystal structure: M. Hospital et al., Biopolymers 18, 1141 (1979). In crystals, the acetyl group is in the trans conformation and the ring is puckered. The trans form is more stable than the cis form in solutions: W. A. Thomas, M. K. Williams, J. Chem. Soc. Chem. Commun. 1972, 994. Anti-inflammatory and wound-healing activity in animals: P. Coirre, B. Coirre, GB 1246141 (1971) related to P. Coirre et al., US 3891765 and US 3932638 (1975, 1976 both to Franco Chimie). Clinical studies of use in several rheumatic conditions: P. Grellat, Rhumatologie 27, 223 (1975); in degenerative joint disease, R. Schubotz, L. Hausmann, Therapiewoche 27, 4248 (1977); in treatment of burns, tumors and other wounds (applied locally): Y. Privat, Gaz. Med. Fr. 84, 618 (1977).