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Acetoxolone CAS Registry Number: 6277-14-1 乙酰甘草亭酸铝

CAS Name: (3b,20b)-3-(Acetyloxy)-11-oxoolean-12-en-29-oic acid
Additional Names: 3b-hydroxy-11-oxoolean-12-en-30-oic acid acetate; 3-O-acetyl-18b-glycyrrhetic acid; acetylglycyrrhetinic acid; glycyrrhetic acid acetate
Percent Composition: C 74.96%, H 9.44%, O 15.60%

📌 参考资料/链接：
Literature References: Deriv of enoxolone, q.v.; homolog of carbenoxolone, q.v. Prepn: J. M. Beaton, F. S. Spring, J. Chem. Soc. 1955, 3126. Prepn of the aluminum salt: A. Bonati, ZA 7006901; idem, US 3764618 (1971, 1973 both to Dott. Inverni Della Beffa). NMR study of the acetate: M. Mousseron-Canet et al., Bull. Soc. Chim. Fr. 12, 4668 (1967). Pharmacology of the aluminum salt: C. Capra, Fitoterapia 40, 8 (1969), C.A. 73, 64754 (1970). Absorption in rats: B. D. Cameron et al., Arzneim.-Forsch. 26, 1680 (1976). Analysis of gastric protective effect: P. Altmayer et al., ibid. 31, 853 (1981).

📄 详细内容

Properties: Crystals, mp 322-325°. [a]D20 +141°.
Melting point: mp 322-325°
Optical Rotation: [a]D20 +141°
Derivative Type: Aluminum salt
CAS Registry Number: 29728-34-5
Trademarks: Almacet (Celtia)
Percent Composition: C 73.81%, H 9.10%, Al 1.73%, O 15.36%
Properties: White powder, mp 286-290°. [a]D20 +126±2° (c = 1 in chloroform). Insol in water. Sol in most organic solvents. LD50 in male rats (mg/kg): 3300 orally, and i.p. (Bonati).
Melting point: mp 286-290°
Optical Rotation: [a]D20 +126±2° (c = 1 in chloroform)
Toxicity data: LD50 in male rats (mg/kg): 3300 orally, and i.p. (Bonati)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).
产品链接: 6277-14-1››

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