Peplomycin CAS Registry Number: 68247-85-8 派来霉素

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Literature References: Deriv of bleomycin, q.v. with cytostatic activity and less pulmonary toxicity than the natural bleomycin mixture. Prepn of the (R,S)-form: H. Umezawa et al., US 3846400 (1974 to Microbiochem. Res. Found.); of the (S)-form: T. Takita et al., DE 2828933; eidem, US 4195018 (1979, 1980 both to Nippon Kayaku); W. Tanaka et al., Heterocycles 13, 469 (1979). Biological study of degradation products: K. Takahashi et al., J. Antibiot. 32, 36 (1979). General pharmacology: Y. Ishii et al., Jpn. J. Antibiot. 31, 886 (1978), C.A. 91, 215c (1979). Absorption, distribution, excretion, metabolism: H. Takayama et al., ibid. 895, C.A. 91, 32580j (1979). Properties and stability: A. Fuji et al., Iyakuhin Kenkyu 10, 197 (1979), C.A. 91, 9408a (1979). Effect in prostatic cancer: T. Niijima, K. Koiso, Scand. J. Respir. Dis. Suppl. 55, 177 (1980). Relative pulmonary toxicity: B. I. Sikic et al., Cancer Treat. Rep. 64, 659 (1980). Acute toxicity study: K. Ito et al., Jpn. J. Antibiot. 31, 719 (1978), C.A. 91, 68461k (1979). Review of clinical studies: S. Oko, Recent Results Cancer Res. 74, 163 (1980).