其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Coumingine CAS Registry Number: 26241-81-6 (3beta,13E,14alpha)-13-{2-[2-(二甲基氨基)乙氧基]-2-氧代乙亚基}-14-甲基-7-氧代罗汉松n-3-基3-羟基-3-甲基丁酸酯

CAS Name: [2S-(2a,4aa,4bb,7E,8b,8aa,10ab)]-3-Hydroxy-3-methylbutanoic acid 7-[2-[2-(dimethylamino)ethoxy]-2-oxoethylidene]tetradecahydro-1,1,4a,8-tetramethyl-9-oxo-2-phenanthrenyl ester
Percent...
Literature References: Cardiotonic principle from the bark of Erythrophleum couminga Baillon, Leguminosae. Isoln: Ruzicka et al., Helv. Chim. Acta 24, 63 (1941). Structure: Ruzicka et al., ibid. 1449.

Cassaidine CAS Registry Number: 26296-41-3 二氢围涎皮次碱

CAS Name: [1R-(1a,2E,4aa,4bb,7b,8aa,10b,10ab)]-(Dodecahydro-7,10-dihydroxy-1,4b,8,8-tetramethyl-2(1H)-phenanthrenylidene)acetic acid 2-(dimethylamino)ethyl ester
Additional Names: (E)-3b,7b-dih...
Literature References: Cardiotonic principle from the bark of Erythrophleum guineense G. Don., Leguminosae. Isoln and structure: Ruzicka, Dalma, Helv. Chim. Acta 23, 753 (1940); Engel, ibid. 42, 1127 (1959). Synthesis: Turner et al., J. Am. Chem. Soc. 88, 1766 (1966). Stereochemistry: Clarke et al., ibid. 88, 5865 (1966).

Lycopene CAS Registry Number: 502-65-8 番茄红素

CAS Name: y,y-Carotene
Additional Names: (all-trans)-lycopene
Percent Composition: C 89.49%, H 10.51%
Literature References: Carotenoid antioxidant occurring in ripe fruit, especially in tomatoes. One kg of fresh ripe tomatoes yields 0.02 g lycopene. Isoln procedure: R. Willstätter, H. H. Escher, Z. Physiol. Chem. 64, 47 (1910). Chromatographic sepn from other carotenoids: A. Winterstein, ibid. 215, 51 (1933); A. Winterstein, G. Stein, ibid. 220, 247 (1933). HPLC determn in plasma: M. V. Vertzoni et al., J. Chromatogr. B 819, 149 (2005). Structure: Willstätter, Escher, loc. cit.; Karrer and collaborators: Helv. Chim. Acta 11, 751, 1201 (1928); 12, 285 (1929); 13, 1084 (1930); 14, 435 (1931); Kuhn, Grundmann, Ber. 65, 898, 1880 (1932). Synthesis: P. Karrer et al., Helv. Chim. Acta 33, 1349 (1950); O. Isler et al., ibid. 39, 463 (1956). Commercial prepn: Kabbe et al., DE 1168890 (1964 to Bayer). Oral toxicity study: W. Mellert et al., Food Chem. Toxicol. 40, 1581 (2002). Review of antioxidant activity and role in human health: A. V. Rao, S. Agarwal, Nutr. Res. 19, 305-323 (1999).

Lycoxanthin CAS Registry Number: 19891-74-8 番茄黃素

CAS Name: y,y-Carotene-16-ol
Additional Names: (all-trans)-lycopen-16-ol
Percent Composition: C 86.90%, H 10.21%, O 2.89%
Literature References: Carotenoid isolated from Solanum dulcamara L., Lycopersicum esculentum Mill., Solanaceae; Tamus communis L., Dioscoreaceae. Isoln by chromatography and structure: Zechmeister, Cholnoky, Ber. 69, 422 (1936). Structure: Karrer et al., Helv. Chim. Acta 13, 268, 1084 (1930); 14, 614, 843 (1931); Winterstein, Angew. Chem. 72, 902 (1960). Revised structure: Cholnoky, Szabolcs, Tetrahedron Lett. 1968, 1931. Stereochemistry: Kelly et al., Acta Chem. Scand. 25, 1607 (1971). Total synthesis: Kjosen, Liaaen-jensen, ibid. 1500.

Rubixanthin CAS Registry Number: 3763-55-1 3-羥-Γ-胡蘿蔔素

CAS Name: (3R)-b,y-Caroten-3-ol
Percent Composition: C 86.90%, H 10.21%, O 2.89%
Literature References: Carotenoid isomeric with cryptoxanthin. Isolated from hipberries (rose hips, Rosa rubiginosa L., Rosaceae): Kuhn, Grundmann, Ber. 67, 339, 1133 (1934); from the flowers of Tagetes patula L., Compositae. Found also in other Rosa varieties. Structural studies: Brown, Weedon, Chem. Commun. 1968, 382. Abs config: L. Bartlett et al., J. Chem. Soc. C 1969, 2527. Biosynthesis studies: McDermott et al., Biochem. J. 134, 1115 (1973). Has no vitamin A activity.

Fucoxanthin CAS Registry Number: 3351-86-8 岩藻黄质

CAS Name: (3S,3'S,5R,5'R,6S,6'R)-3'-(Acetyloxy)-6',7'-didehydro-5,6-epoxy-5,5',6,6',7,8-hexahydro-3,5'-dihydroxy-8-oxo-b,b-carotene
Additional Names: 6',7'-didehydro-5,6-epoxy-4',5,5',6,7,8-hex...
Literature References: Carotenoid pigment found in fresh brown algae: Fucus virsoides (Don) J. Ag., Fucaceae. Also found in Zygnema pectinatum (Vauch.) Ag., Zygnemaceae and in Polysiphonia nigrescens (Dillw.) Grev., Rhodomelaceae. Isoln: Karrer et al., Helv. Chim. Acta 14, 628 (1931); Willstätter, Page, Ann. 404, 237 (1914). Structure: Bonnet et al., Chem. Commun. 1966, 515; J. Chem. Soc. C 1969, 429. Abs config: DeVille et al., Chem. Commun. 1969, 1311; K. Bernhard et al., Tetrahedron Lett. 1976, 115.

Torularhodin CAS Registry Number: 514-92-1 红酵母红素

CAS Name: 3',4'-Didehydro-b,y-caroten-16'-oic acid
Percent Composition: C 85.06%, H 9.28%, O 5.67%
Literature References: Carotenoid pigment found in Torula rubra and Rhodotorula mucilaginosa yeasts. Isoln: Karrer, Rutschmann, Helv. Chim. Acta 26, 2109 (1943). Structure and synthesis: Isler et al., ibid. 42, 864 (1959).

Rhodoxanthin CAS Registry Number: 116-30-3 玫红黄质

CAS Name: 4',5'-Didehydro-4,5-retro-b,b-carotene-3,3'-dione
Percent Composition: C 85.36%, H 8.95%, O 5.69%
Literature References: Carotenoid pigment found widely distributed in nature, but in very small amounts only. One of very few carotenoids with retro configuration. Best isolated from the arils of Taxus baccata L., Taxaceae: Kuhn, Brockmann, Ber. 66, 828 (1933). Occurs also in the feathers of birds such as Phoenicircus nigricollis, Megaloprepia magnifica. Isoln: Volker, Z. Physiol. Chem. 292, 75 (1953). Structure: Kuhn, Brockmann, loc. cit.; Karrer, Solmssen, Helv. Chim. Acta 18, 477 (1935). Synthesis: Mayer et al., ibid. 50, 1606 (1967); Surmatis, Walser, US 3466331; US 3624105 (1969, 1971 to Hoffmann-La Roche); P. R. Ellis et al., Helv. Chim. Acta 64, 1092 (1981); E. Widmer et al., ibid. 65, 944 (1982). Review: Liaaen-Jensen in Aspects Terpenoid Chem. Biochem., Proc. Phytochem. Soc. Symp., 2nd, 1970, T. W. Goodwin, Ed. (Academic Press, London, 1971) p 223-254.

Rhodoviolascin CAS Registry Number: 34255-08-8

CAS Name: 3,3',4,4'-Tetradehydro-1,1',2,2'-tetrahydro-1,1'-dimethoxy-y,y-carotene
Additional Names: 3,3',4,4'-tetradehydro-1,1',2,2'-tetrahydro-1,1'-dimethoxylycopene; spirilloxanthin
Percen...
Literature References: Carotenoid pigment isolated from Rhodovibrio and Thioceptis bacteria: Karrer, Solmssen, Helv. Chim. Acta 18, 1306 (1935). Identity with spirilloxanthin: Zechmeister et al., Arch. Biochem. 5, 243 (1944). Structure: Karrer, Koenig, Helv. Chim. Acta 23, 460 (1940); Barber et al., Proc. Chem. Soc. London 1959, 96. Synthesis: Surmatis, Ofner, J. Org. Chem. 28, 2735 (1963); Surmatis, US 3160658 (1964 to Hoffmann-La Roche).

Echinenone CAS Registry Number: 432-68-8 松果菊酮

CAS Name: b,b-Caroten-4-one
Additional Names: 4-oxo-b-carotene; 4-keto-b-carotene; aphanin; myoxanthin
Percent Composition: C 87.21%, H 9.88%, O 2.90%
Literature References: Carotenoid pigment occurring in algae. Isoln from Aphanizomenon flos-aqua: Tischer, Z. Physiol. Chem. 251, 109 (1938); 260, 257 (1939); from Paracentrotus lividus: Lederer, Compt. Rend. 201, 300 (1935); from Oscillatoria rubrescens: Heilbron, Lythgoe, J. Chem. Soc. 1936, 1376. Structure: Goodwin, Taha, Biochem. J. 47, 244 (1950); 48, 513 (1951); Goodwin, ibid. 63, 481 (1956); Ganguly et al., Arch. Biochem. Biophys. 60, 345 (1956). Synthesis: Akhtar, Weedon, J. Chem. Soc. 1958, 3986; 1959, 4058.