其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tripamide CAS Registry Number: 73803-48-2 卓波酰胺

CAS Name: (3aa,4a,7a,7aa)-3-(Aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)benzamide
Additional Names: 4-chloro-N-(endo-hexahydro-4,7-methanoisoindolin-2-yl)-3-sulfamoylbenz...
Literature References: Sulfonamide with diuretic and peripheral vasodilator activity. Prepn: H. Hamano et al., JP 73 5585 (1973 to Eisai), C.A. 78, 136070r (1973). Synthesis of 14C-tripamide: T. Nakamura et al., J. Labelled Compd. Radiopharm. 14, 191 (1978). Pharmacological study: T. Satoh et al., Oyo Yakuri 21, 607 (1981), C.A. 96, 28414u (1982). Metabolism: T. Horie et al., Xenobiotica 11, 197, 693 (1981).

Amosulalol CAS Registry Number: 85320-68-9 氨磺洛尔

CAS Name: 5-[1-Hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methylbenzenesulfonamide
Percent Composition: C 56.82%, H 6.36%, N 7.36%, O 21.03%, S 8.43%
Literature References: Sulfonamide-substituted phenylethanolamine with a- and b-adrenergic blocking activity. Prepn: K. Imai et al., DE 2843016; eidem, US 4217305 (1979, 1980 both to Yamanouchi). Pharmacology and receptor blocking activity: T. Takenaka et al., Eur. J. Pharmacol. 85, 35 (1982); of isomers: K. Honda et al., J. Pharmacol. Exp. Ther. 236, 776 (1986). GC determn in urine: H. Kamimura et al., J. Chromatogr. 275, 81 (1983); HPLC determn in plasma: H. S. Gwak et al., J. Chromatogr. B 818, 109 (2005). Clinical pharmacokinetics: M. Nakashima et al., Clin. Pharmacol. Ther. 36, 436 (1984); metabolism: H. Kamimura et al., Xenobiotica 15, 413 (1985). Clinical evaluation in hypertension: K. Ando et al., J. Cardiovasc. Pharmacol. 20, 7 (1992).

Exisulind CAS Registry Number: 59973-80-7 2-[(3Z)-6-氟-2-甲基-3-[(4-甲基磺酰基苯基)亚甲基]茚-1-基]乙酸

CAS Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic acid
Additional Names: cis-5-fluoro-2-methyl-1-(p-methylsulfonylbenzylidene)-3-acetic acid; sulindac ...
Literature References: Sulfone metabolite of sulindac, q.v.; induces apoptosis of cancer cells. Identification as metabolite: H. B. Hucker et al., Drug Metab. Dispos. 1, 721 (1973). Prepn: H. Jones et al., J. Carbohydr. Nucleosides Nucleotides 3, 369 (1974). Antiproliferative effect vs colon cancer cells: L. J. Hixson et al., Cancer Epidemiol. Biomarkers Prev. 3, 433 (1994). HPLC determn in serum: M. Siluveru, J. T. Stewart, J. Chromatogr. B 673, 91 (1995); and clinical pharmacokinetics: G. F. Ray et al., J. Pharm. Biomed. Anal. 14, 213 (1995). Review of mechanism of action studies: D. J. Ahnen, Eur. J. Surg. Suppl. 582, 111-114 (1998).

Triasulfuron CAS Registry Number: 82097-50-5 醚苯磺隆

CAS Name: 2-(2-Chloroethoxy)-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide
Additional Names: 1-[2-(2-chloroethoxy)phenylsulfonyl]-3-(4-methoxy-6-methyl-1,3,5-tria...
Literature References: Sulfonylurea herbicide for broadleaf weeds. Prepn: W. Meyer, W. Föry, EP 44808; eidem, US 4514212 (1982, 1985 both to Ciba-Geigy). Comprehensive description: J. Amrein, H. R. Gerber, Proc. Br. Crop Prot. Conf. - Weeds 1985, 55-62. Uptake and metabolism in wheat: A. M. Meyer, F. Müller, Brighton Crop Prot. Conf. - Weeds 1989, 441. Behavior in soil: F. K. Oppong, G. R. Sagar, Weed Res. 32, 157, 167 (1992). Immunoassay in soil: J. A. Schlaeppi et al., J. Agric. Food Chem. 42, 1914 (1994).

Thifensulfuron-methyl CAS Registry Number: 79277-27-3 噻吩磺隆

CAS Name: 3-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
Additional Names: methyl 3-(3-(4-methoxy-6-methyl-1,3,5-triazin-2-y...
Literature References: Sulfonylurea herbicide for postemergence broadleaf weed control in food crops. Prepn: G. Levitt, EP 30142; idem, US 4481029 (1981, 1984 both to DuPont). Degradation in soil: H. M. Brown et al., J. Agric. Food Chem. 45, 955 (1997). HPLC determn in cotton seed: J. J. Stry et al., J. AOAC Int. 83, 651 (2000). Metabolism in soybeans: H. M. Brown et al., Pestic. Biochem. Physiol. 37, 303 (1990). Review of physical properties, mode of action and field trials: S. D. Sionis et al., Proc. Br. Crop Prot. Conf. - Weeds 1985, 49-54.

Iodosulfuron-methyl-sodium CAS Registry Number: 144550-36-7 碘甲磺隆钠盐

CAS Name: 4-Iodo-2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester monosodium salt
Additional Names: methyl 4-iodo-2-[3-(4-methoxy-6-methyl-1,...
Literature References: Sulfonylurea herbicide for post-emergence use in cereals; acetolactate synthase inhibitor. Prepn: O. Ort et al., WO 9213845; eidem, US 5688745 (1992, 1997 both to Hoechst). Comprehensive description and use with the safener, mefenpyr-diethyl: E. Hacker et al., Brighton Crop Prot. Conf. - Weeds 1999, 15-22. Field trials in wheat: H. L. Crooks et al., Weed Technol. 18, 93 (2004).

Triflusulfuron-methyl CAS Registry Number: 126535-15-7 氟胺磺隆

CAS Name: 2-[[[[[4-(Dimethylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino]carbonyl]amino]sulfonyl]-3-methyl benzoic acid methyl esterTrademarks: Debut (DuPont); Safari (DuPont); Upbeet...
Literature References: Sulfonylurea herbicide for use in beets; acetolactate synthase inhibitor. Prepn: M. P. Moon, WO 8909214; idem, US 5090993 (1989, 1992 both to DuPont). Comprehensive description: K. A. Peeples et al., Brighton Crop Prot. Conf. - Weeds 1991, 25-30. Selectivity in sugar beets: V. A. Wittenbach et al., Pestic. Biochem. Physiol. 49, 72 (1994).

Foramsulfuron CAS Registry Number: 173159-57-4 甲酰氨基嘧磺隆

CAS Name: 2-[[[[(4,6-Dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-4-(formylamino)-N,N-dimethylbenzamideTrademarks: Option (Bayer CropSci.)
Percent Composition: C 45.13%, H 4.46%, N 18...
Literature References: Sulfonylurea herbicide for use in corn; acetolactate synthase inhibitor. Prepn: G. Schnabel et al., DE 4415049; eidem, US 5922646 (1995, 1999 both to Hoechst Schering AgrEvo). Review of properties and activity: B. Collins et al., BCPC Conf. - Weeds 2001, 35-42.

Sulfosulfuron CAS Registry Number: 141776-32-1 磺酰磺隆

CAS Name: N-[[(4,6-Dimethoxy-2-pyrimidinyl)amino]carbonyl]-2-(ethylsulfonyl)imidazo[1,2-a]pyridine-3-sulfonamide
Additional Names: 1-(2-ethylsulfonylimidazol[1,2-a]pyridin-3-ylsulfonyl)-3-(4,6-...
Literature References: Sulfonylurea herbicide to control grassy weeds in wheat. Prepn: Y. Ishida et al., EP 477808 (1992 to Takeda). Description of physical properties, toxicity and activity: S. K. Parrish et al., Brighton Crop Prot. Conf. - Weeds 1995, 57. Soil degradation: idem et al., ibid. 667. Field trial in winter wheat: R. E. Blackshaw, W. M. Hamman, Weed Technol. 12, 421 (1998). Absorption and translocation in grass species: B. L. S. Olson et al., Weed Sci. 47, 37 (1999).

Flazasulfuron CAS Registry Number: 104040-78-0 啶嘧磺隆

CAS Name: N-[[(4,6-Dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(trifluoromethyl)-2-pyridinesulfonamide
Additional Names: 1-(4,6-dimethoxypyrimidin-2-yl)-3-(3-trifluoromethyl-2-pyridylsulfonyl)ure...
Literature References: Sulfonylurea herbicide. Prepn: F. Kimura et al., EP 184385; eidem, US 4744814 (1986, 1988 both to Ishihara Sangyo Kaisha); T. Haga et al., ACS Symp. Ser. 443, 107 (1991). Description of properties and biological activity: B. Hashizume, Jpn. Pestic. Inf. 57, 27 (1990). Field trial for control of ragwort: T. K. James et al., Proc. 50th N. Z. Plant Prot. Conf. 1997, 447. Weed control management in grapevines: P. Bourdrez, J.-M. Béraud, Phytoma 521, 66 (1999).