其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Alsactide CAS Registry Number: 34765-96-3 阿沙克肽

CAS Name: 1-b-Alanine-17-[N-(4-aminobutyl)-L-lysinamide]-a1-17-corticotropin
Additional Names: 1-b-alanine-17-[L-2,6-diamino-N-(4-aminobutyl)hexanamide]-a1-17-corticotropin; [b-ala1,lys17]corti...
Literature References: Short-chain ACTH analog. Synthesis: R. Geiger, H. G. Schroeder, DE 1954794; eidem, US 3749704 (1971, 1973, both to Hoechst); R. Geiger, Ann. 750, 165 (1971). Pharmacology: J. Sandow et al., Arch. Pharmacol. 297, Suppl. 2, R41 (1977). Dose dependent effects on cortisol and aldosterone plasma levels in man: A. Angeli et al., Horm. Metab. Res. 13, 24 (1981). Review of chronobiological activity: idem et al., Chronobiologica 14, 99-143 (1987).

Dimethicone CAS Registry Number: 9006-65-9 聚二甲基硅氧烷

Additional Names: Dimethyl polysiloxane; dimeticon; polydimethylsiloxane; a-(trimethylsilyl)-w-methylpoly[oxy(dimethylsilylene)]
Literature References: Silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units. Prepn of homologous liquid methyl siloxane polymers: J. F. Hyde, US 2441098 (1948 to Corning Glass). Dimethicone mixed with silicon dioxide is known as simethicone. Clinical evaluation of simethicone in functional upper GI disease: J. E. Bernstein, A. M. Kasich, J. Clin. Pharmacol. 14, 617 (1974). Stability of simethicone + antacid mixtures in pharmaceutical preparations: J. A. Rider, Curr. Ther. Res. 52, 681 (1992). Review of use of dimethicones in skin and hair products: A. Disapio, P. Fridd, Int. J. Cosmet. Sci. 10, 75-89 (1988). Review of medical use in soft-tissue augmentation: V. J. Selmanowitz, N. Orentreich, J. Dermatol. Surg. Oncol. 3, 597-611 (1977); D. M. Duffy, Adv. Dermatol. 5, 93-109 (1990). See also: Silicones.

Silver Carbonate CAS Registry Number: 534-16-7 负载碳酸银

CAS Name: Carbonic acid disilver(1+) salt
Percent Composition: C 4.36%, Ag 78.24%, O 17.41%
Literature References: Silver carbonate pptd on Celite, q.v., is known as Fétizon's reagent. Thermal decompn studies: M. Centnerszwer, B. Bruzs, J. Phys. Chem. 29, 733 (1925); P. Norby et al., 41, 3628 (2002). Prepn from silver nitrate and sol carbonate soln: Poyer et al., Inorg. Synth. 5, 19 (1957). Crystal structure: R. Masse et al., Acta Crystallogr. B35, 1428 (1979). Mechanism of alcohol oxidation using silver carbonate pptd on celite: M. Fetizon, M. Golfier, C.R. Acad. Sci. Ser. C 267, 900 (1968); M. Fetizon et al., Tetrahedron Lett. 13, 4445 (1972); F. J. Kakis et al., J. Org. Chem. 39, 523 (1974). Biological staining method: J. M. López-Cepero, J. Histochem. Cytochem. 52, 211 (2004).

Hexamethyldisilazane CAS Registry Number: 999-97-3 六甲基二硅氮烷

CAS Name: 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
Additional Names: HMDS
Percent Composition: C 44.65%, H 11.87%, N 8.68%, Si 34.80%
Literature References: Silylating agent. Prepn: R. O. Sauer, J. Am. Chem. Soc. 66, 1707 (1944). Surface tension and density as a function of temperature: R. S. Myers, H. L. Clever, J. Chem. Eng. Data 14, 161 (1969). Mass spec. study: J. Tamás, P. Miklos, Org. Mass Spectrom. 10, 859 (1975). Raman, IR and NMR spectra: K. Hamada, H. Morishita, Spectrosc. Lett. 16, 717 (1983). Molecular structure and conformation: T. Fjeldberg, J. Mol. Struct. 112, 159 (1984). Use in deactivation of chromatography columns: T. Welsch et al., J. Chromatogr. 241, 41 (1982); R. C. Kong et al., Chromatographia 18, 362 (1984). Use as adhesion promoter for photoresists: J. N. Helbert, H. G. Hughes in Proc. Symp. Adhesion Aspects Polymeric Coatings, K. L. Mittal, Ed. (Plenum Press, New York, 1983) pp 499-508; D. Freeman, W. Kern, J. Vac. Sci. Technol. A 7, 1446 (1989). Physical properties, toxicity and technical data: Petrarch Systems Inc. Product Information Sheets. Brief review of chemistry and applications: R. J. De Pasquale, Am. Lab. 5(6), 35-39 (1973).

b -Erythroidine CAS Registry Number: 466-81-9 Β-刺桐定碱

CAS Name: (3b)-1,2,6,7-Tetradehydro-14,17-dihydro-3-methoxy-16(15H)-oxaerythrinan-15-one
Additional Names: 12,13-didehydro-13,14-dihydro-a-erythroidine
Percent Composition: C 70.31%, H 7.01%...
Literature References: Skeletal muscle relaxant. Isolated from the seeds and other plant parts of Erythrina spp., Leguminosae: Folkers, Major, J. Am. Chem. Soc. 59, 1580 (1937); eidem, US 2373952; US 2385266; US 2407713 (1945 and 1946 to Merck Co.). Structural studies: Koniuszy, Folkers, J. Am. Chem. Soc. 72, 5519 (1950); Boekelheide et al., ibid. 75, 2550 (1953). Absolute configuration: Wenzinger, Boekelheide, Proc. Chem. Soc. London 1963, 53; eidem, J. Org. Chem. 29, 1307 (1964). Toxicity data: F. M. Berger, R. P. Schwartz, J. Pharmacol. Exp. Ther. 93, 362 (1948). Review: Boekelheide, Rec. Chem. Prog. 16, 227-239 (1955).

Tioclomarol CAS Registry Number: 22619-35-8 噻氯香豆素

CAS Name: 3-[3-(4-Chlorophenyl)-1-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-[5-chloro-a-(p-chloro-b-hydroxyphenethyl)-2-thenyl]-4-hydroxycoumarin...
Literature References: Slow-acting anticoagulant, related structurally to warfarin, q.v. Prepn: E. Boschetti et al., ZA 6707267 corresp to US 3574234 (1968, 1971 both to Lipha). Synthesis and anticoagulant activity: eidem, Chim. Ther. 7, 20 (1972).

Campesterol CAS Registry Number: 474-62-4 菜油甾醇

CAS Name: (3b,24R)-Ergost-5-en-3-ol
Percent Composition: C 83.93%, H 12.07%, O 3.99%
Literature References: Small amounts are found in rape-seed oil derived from Brassica campestris L., Cruciferae, in soybean oil, and in wheat germ oil. Isoln: Fernholz, MacPhillamy, J. Am. Chem. Soc. 63, 1155 (1941). Structure: Fernholz, Ruigh, ibid. 1157. Synthesis: Tarzia et al., Gazz. Chim. Ital. 97, 102 (1967), C.A. 67, 32883q (1967).

Pifithrin- a CAS Registry Number: 63208-82-2 2-(2-亚氨基-4,5,6,7-四氢苯并噻唑-3-基)-1-P-苯甲基乙酮氢溴酸盐

CAS Name: 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone monohydrobromide
Additional Names: 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hyd...
Literature References: Small molecule inhibitor of p53-mediated gene activation and apoptosis; the name pifithrin is an abbreviation for p-fifty three inhibitor. Converted in vitro to the planar tricyclic condensation product, pifithrin-b. Prepn: A. Singh et al., Indian J. Chem. 14B, 997 (1976). Identification of p53 inhibition: P. G. Komarov et al., Science 285, 1733 (1999). Synthesis and neuroprotective activity: X. Zhu et al., J. Med. Chem. 45, 5090 (2002). Inhibition of heat shock and glucocorticoid signal transduction pathways: E. A. Komarova et al., J. Biol. Chem. 278, 15465 (2003). Characterization as an aryl hydrocarbon receptor agonist: M. S. Hoagland et al., J. Pharmacol. Exp. Ther. 314, 603 (2005). Conversion to pifithrin-b: R. K. Gary, D. A. Jensen, Mol. Pharm. 2, 462 (2005).

Blebbistatin CAS Registry Number: 674289-55-5 布雷比司他汀

CAS Name: 1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Additional Names: 1-phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one
Percen...
Literature References: Small molecule inhibitor of the ATPase activity of myosin II; affects cell blebbing during cell division. Prepn and inhibition of non-muscle myosin II: A. F. Straight et al., Science 299, 1743 (2003). Prepn and crystal structure of (-)-form: C. Lucas-Lopez et al., Eur. J. Org. Chem. 2005, 1736. Crystal structure in complex with myosin II: J. S. Allingham et al., Nat. Struct. Mol. Biol. 12, 378 (2005). Kinetics of non-muscle myosin IIB inhibition: B. Ramamurthy et al., Biochemistry 43, 14832 (2004). Mechanism of myosin II inhibition: M. Kovács et al., J. Biol. Chem. 279, 35557 (2004). Photochemistry studies: J. Kolega, Biochem. Biophys. Res. Commun. 320, 1020 (2004); T. Sakamoto et al., Biochemistry 44, 584 (2005).

Proxyphylline CAS Registry Number: 603-00-9 7-(2-羟丙基)茶碱

CAS Name: 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2-hydroxypropyl)theophylline
Trademarks: Brontyl (Reckitt Benckiser); Spasmolysin (Kade); Theo...
Literature References: Smooth muscle relaxant. Prepd by refluxing 1-chloro-2-propanol with theophylline in an alkaline medium: Rice, US 2715125 (1955 to Gane's Chem. Works).