其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Thapsigargin CAS Registry Number: 67526-95-8 毒胡萝卜素

CAS Name: Octanoic acid [3S-[3a,3ab,4a,6b,6ab,7b,8a(Z),9ba]]-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)az...
Literature References: Sesquiterpene lactone which inhibits intracellular Ca2+ transport ATPases. Isolated from the root of Thapsia garganica L., Apiaceae, traditionally used as a counter-irritant: U. Rasmussen et al., Acta Pharm. Suec. 15, 133 (1978). Structure elucidation: S. B. Christensen et al., Tetrahedron Lett. 21, 3829 (1980); stereochemistry from x-ray analysis: idem et al., J. Org. Chem. 47, 649 (1982). Absolute configuration: S. B. Christensen, E. Norup, Tetrahedron Lett. 26, 107 (1985). Inhibition of ATPases: J. Lytton et al., J. Biol. Chem. 266, 17067 (1991). Effect on gene expression: K. D. Rodland et al., Mol. Endocrinol. 11, 281 (1997). Review of mechanism of action: G. Inesi, Y. Sagara, Arch. Biochem. Biophys. 298, 313-317 (1992). Review of use as molecular probe: O. Thastrup et al., Agents Actions 27, 17-23 (1989); T. B. Rogers et al., Biosci. Rep. 15, 341-349 (1995).

Coriamyrtin CAS Registry Number: 2571-86-0 马桑内酯

CAS Name: (1aS,1bR,2S,2'R,5S,6aR,7aR,8R)-Hexahydro-1b-hydroxy-6a-methyl-8-(1-methylethenyl)spiro[2,5-methano-7H-oxireno[3,4]cyclopent[1,2-d]oxepin-7,2'-oxiran]-3(2H)-one
Percent Composition: C ...
Literature References: Sesquiterpene of the picrotoxane group. Main toxic principle from leaves and fruit of Coraria myrtifolia L., Coriariaceae: M. J. Riban, C.R. Hebd. Seances Acad. Sci. 57, 798 (1863) and C. japonica A. Gray, Coriariaceae: Kariyone, Sato, J. Pharm. Soc. Jpn. 50, 106 (1930); Okuda, Pharm. Bull. 2, 185 (1954). Series of articles on structure, absolute configuration, stereochemistry and derivatives: T. Okuda, T. Yoshida, Chem. Pharm. Bull. 9, 379, 404 (1961); 15, 1687, 1697 (1967). Structural relationship to tutin, q.v.: eidem, Tetrahedron Lett. 1965, 439. Biosynthetic studies: M. Biollaz, D. Arigoni, Chem. Commun. 1969, 633. Synthetic studies: K. Tanaka et al., Chem. Pharm. Bull. 31, 1943, 1958, 1972 (1983). Pharmacology: E. E. Swanson, K. K. Chen, J. Pharmacol. Exp. Ther. 57, 410 (1936). Structure-activity relationship: C. H. Jarboe et al., J. Med. Chem. 11, 729 (1968).

Humulene CAS Registry Number: 6753-98-6 α-石竹烯

CAS Name: (1E,4E,8E)-2,6,6,9-Tetramethyl-1,4,8-cycloundecatriene
Additional Names: a-humulene; a-caryophyllene
Percent Composition: C 88.16%, H 11.84%
Literature References: Sesquiterpenoid isomer of caryophyllene, q.v. occurring in many essential oils, especially oil of hops (Humulus lupulus L. Moraceae) and leaves of Lindera strychnifolia (F.) Will Lauraceae. Occurs in nature as a mixture with b-humulene. Isolation of mixture: A. C. Chapman, J. Chem. Soc. 67, 54, 780 (1895). Identity with a-caryophyllene: F. Sorm et al., Collect. Czech. Chem. Commun. 14, 693, 699, 716 (1949). Structure: F. Sorm et al., ibid. 19, 570 (1954). Stereochemistry: A. T. McPhail, G. A. Sim, J. Chem. Soc. B 1966, 112. Synthesis: E. J. Corey, E. Hanamaka, J. Am. Chem. Soc. 89, 2758 (1967). Stereoselective synthesis: Y. Kitagawa et al., ibid. 99, 3864 (1977); E. J. Corey et al., Tetrahedron Lett. 34, 3675 (1993). Chromatographic conversion to b-humulene: V. Benesova et al., Collect. Czech. Chem. Commun. 26, 1832 (1961). Reviews: F. Sorm in Fortschr. Chem. Org. Naturst. 19, 1-32 (1961); Rodd's Chemistry of Carbon Compounds vol. IIC, S. Coffey, Ed., (Elsevier, New York, 2nd ed., 1969) pp 282-283.

Caryophyllene CAS Registry Number: 87-44-5 反式石竹烯

CAS Name: (1R,4E,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene
Additional Names: b-caryophyllene; trans-caryophyllene
Percent Composition: C 88.16%, H 11.84%
Literature References: Sesquiterpenoid occurring in many essential oils and especially in clove oil, the oils from stems and flowers of Syzygium aromaticum (L.) Merrill Perry (Jambrosa caryophyllus Niedenzu; Eugenia caryophyllata Thunb.), Myrtaceae. Occurs in nature as a mixture with isocaryophyllene and a-caryophyllene (humulene, q.v.). Isolation of mixture: Schreiner, Kremers, Pharm. Arch. 2, 273, 293 (1899). Existence of isomers: Deussen, Ann. 356, 1 (1907). Structural studies: A. Aebi et al., J. Chem. Soc. 1953, 3124; G. R. Ramage, R. Whitehead, ibid. 1954, 4336. Abs config: D. H. R. Barton, A. Nickon, ibid. 4665. Total synthesis of racemic trans/cis-forms: E. J. Corey et al., J. Am. Chem. Soc. 86, 485 (1964). Rearrangement to isocaryophyllene: Rachlin, DE 2044018 (1971 to I.F.F.), C.A. 75, 49364j (1971). Reviews: Simonsen, The Terpenes vol. III (University Press, Cambridge, 1952) pp 39-71; Barton, de Mayo, Q. Rev. Chem. Soc. 11, 197 (1957); Halsall, ibid. 16, 101 (1962).

Ilimaquinone CAS Registry Number: 71678-03-0 伊利马醌

CAS Name: 3-[[(1R,2S,4aS,8aS)-Decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione
Additional Names: IQ
Percent Composition: C 73.71...
Literature References: Sesquiterpenoid quinone isolated from the marine sponge, Hippiospongia metachromia; naturally occurring as (-)-form. Inhibits cellular secretions by selective breakdown of the Golgi apparatus. Isoln and structure determn: R. T. Luibrand et al., Tetrahedron 35, 609 (1979). Revised stereochemistry: R. J. Capon, J. K. MacLeod, J. Org. Chem. 52, 5059 (1987). Total stereosynthesis: S. D. Bruner et al., ibid. 60, 1114 (1995); increased yield: S. Poigny et al., ibid. 63, 5890 (1998). Photoaffinity study on cellular targets: H. S. Radeke, M. N. L. Snapper, Bioorg. Med. Chem. 6, 1227 (1998). Mechanism of action studies: P. A. Takizawa et al., Cell 73, 1079 (1993); H. S. Radeke et al., Chem. Biol. 6, 639 (1999). Use as inhibitor of protein secretion: P. A. Feldman et al., J. Membr. Biol. 155, 275 (1997).

Dysidiolide CAS Registry Number: 182136-94-3

CAS Name: (5R)-5-Hydroxy-4-[(1R)-1-hydroxy-2-[(1R,2R,5S,8aS)-1,2,3,5,6,7,8,8a-octahydro-1,2,5-trimethyl-5-(4-methyl-4-pentenyl)-1-naphthalenyl]ethyl]-2(5H)-furanone
Additional Names: (-)-dysidi...
Literature References: Sesterterpene g-hydroxybutenolide with a unique carbon skeleton isolated from the marine sponge Dysidea etheria de Laubenfels. First naturally occurring inhibitor of the protein phosphatase, cdc25; the inhibition of which blocks cell division. Isolation, activity and crystal structure: S. P. Gunasekera et al., J. Am. Chem. Soc. 118, 8759 (1996). Enantioselective synthesis: E. J. Corey, B. E. Roberts, ibid. 119, 12425 (1997). Total synthesis of racemate and preliminary biological activity: S. R. Magnuson et al., ibid. 120, 1615 (1998).

Looplure CAS Registry Number: 14959-86-5 (Z)-7-十二碳烯-1-醇乙酸酯

CAS Name: (Z)-7-Dodecen-1-ol acetate
Additional Names: cis-7-dodecenyl acetate; cis-1-acetoxy-7-dodecenePercent Composition: C 74.28%, H 11.58%, O 14.14%
Literature References: Sex pheromone of the female cabbage looper moth, Trichoplusia ni (Hübner). Isoln, identification and synthesis: R. S. Berger, Ann. Entomol. Soc. Am. 59, 767 (1966). Synthesis and activity of isomers: N. Green et al., J. Med. Chem. 10, 533 (1967); H. H. Toba et al., J. Econ. Entomol. 63, 1048 (1970). Alternate syntheses: W. Seidel et al., Ber. 110, 3544 (1977); H. J. Bestmann et al., Ber. 112, 1923 (1979); M. Horiike, C. Hirano, Agric. Biol. Chem. 44, 2229 (1980); D. Basavaiah et al., J. Org. Chem. 47, 1792 (1982). Acute toxicity study: M. Beroza et al., Toxicol. Appl. Pharmacol. 31, 421 (1975).

Muscalure CAS Registry Number: 27519-02-4 顺-9-二十三烯

CAS Name: (Z)-9-Tricosene
Additional Names: cis-tricos-9-ene
Percent Composition: C 85.63%, H 14.37%
Literature References: Sex pheromone of the female common house fly, Musca domestica L. Isoln and synthesis: Carlson et al., Science 174, 76 (1971). Alternate syntheses: Eiter, Naturwissenschaften 59, 468 (1972); Cargill, Rosenblum, J. Org. Chem. 37, 3971 (1972); Gribble et al., Chem. Commun. 1973, 735; Ho, Wong, Can. J. Chem. 52, 1923 (1974); K. Abe et al., Bull. Chem. Soc. Jpn. 50, 2792 (1977); V. N. Odinokov et al., Tetrahedron Lett. 23, 1371 (1982). Acute toxicity study: M. Beroza et al., Toxicol. Appl. Pharmacol. 31, 421 (1975).

Japonilure CAS Registry Number: 64726-91-6 (R,z)-5-(1-癸基)二氢呋喃-2(3h)-酮

CAS Name: [R-(Z)]-5-(1-Decenyl)dihydro-2(3H)-furanone
Additional Names: [(4R,5Z)]-tetradecen-4-olide; (R,Z)-5-(dec-1-enyl)oxacyclopentan-2-one; IN-60
Percent Composition: C 74.95%, H 10.78%,...
Literature References: Sex pheromone produced by the female Japanese beetle, Popillia japonica Newman (Coleoptera: Scarabaeidae); biological activity is inhibited by its antipode. Isoln and synthesis: J. H. Tumlinson et al., Science 197, 789 (1977). Description of attractant activity: J. H. Tumlinson in Adv. Pest. Sci., 4th Int. Congr. Pest. Chem. 2, H. Geissbühler, Ed (Pergamon Press, Oxford, England, 1979) 315-322. Use in beetle traps: T. L. Ladd, Jr., M. G. Klein, J. Econ. Entomol. 79, 84 (1986); A. Martins et al., Ecol. Bull. 39, 101 (1988). Stereospecific synthesis: S. Chattopadhyay et al., Synth. Commun. 20, 1299 (1990); T. Ebata et al., Biosci. Biotech. Biochem. 56, 818 (1992). Isolation from Anomala spp. as component of pheromone system and field evaluation: W. S. Leal et al., J. Chem. Ecol. 20, 1643 (1994); W. S. Leal et al., ibid. 1667.

Indiplon CAS Registry Number: 325715-02-4 茚地普隆

CAS Name: N-Methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamidePercent Composition: C 63.81%, H 4.28%, N 14.88%, O 8.50%, S 8.52%
Literature References: Short-acting nonbenzodiazepine sedative; high-affinity a1-selective allosteric potentiator of GABAA receptor function. Prepn: J. P. Dusza et al., US 4521422 (1985 to Am. Cyanamid). See also: idem et al., US 6399621 (2002 to Am. Cyanamid). Receptor binding studies: S. K. Sullivan et al., J. Pharmacol. Exp. Ther. 311, 537 (2004). In vivo pharmacology: A. C. Foster et al., ibid. 547. Review of clinical development: D. N. Neubauer, Expert Opin. Invest. Drugs 14, 1269-1276 (2005).