其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Dalfopristin CAS Registry Number: 112362-50-2 达福普汀(甲磺酸盐)

CAS Name: (26R,27S)-26-[[2-(Diethylamino)ethyl]sulfonyl]-26,27-dihydrovirginiamycin M1
Additional Names: 26-(2-diethylaminoethyl)sulfonylpristinamycin IIBPercent Composition: C 59.11%, H 7.29%,...
Literature References: Semisynthetic polyunsaturated macrolactone type II streptogramin, q.v. Prepn: J.-C. Barriere et al., EP 191662; eidem, US 4668669 (1986, 1987 both to Rhone-Poulenc). In vitro activity: H. C. Neu et al., J. Antimicrob. Chemother. 30, Suppl. A, 83 (1992). HPLC determn in plasma: A. Le Liboux et al., J. Chromatogr. B 708, 161 (1998)

Rifapentine CAS Registry Number: 61379-65-5 利福喷丁

CAS Name: 3-[[(4-Cyclopentyl-1-piperazinyl)imino]methyl]rifamycinTrademarks: Priftin (Aventis)
Percent Composition: C 64.37%, H 7.36%, N 6.39%, O 21.89%
Literature References: Semi-synthetic rifamycin. Prepn: R. Cricchio, V. Arioli, DE 2608218; eidem, US 4002752 (1976, 1977 both to Lepetit). Antibacterial activity: V. Arioli et al., J. Antibiot. 34, 1026 (1981); H. C. Neu, Antimicrob. Agents Chemother. 24, 457 (1983). Pharmacokinetics: A. Assandri et al., J. Antibiot. 37, 1066 (1984). HPLC determn in plasma: E. Riva et al., J. Chromatogr. 553, 35 (1991). Clinical trial in tuberculosis: Natl. Co-op Group Clin. Study Rifapentine, Chin. J. Antibiot. 17, 313 (1992), B.A. 95, 70840 (1993). Review of pharmacology and clinical efficacy: B. Jarvis, H. M. Lamb, Drugs 56, 607-616 (1998).

Cefuzonam CAS Registry Number: 82219-78-1 头孢唑喃

CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: (...
Literature References: Semi-synthetic third generation cephalosporin. Prepn and bactericidal activity: W. V. Curran, A. S. Ross, FR 2488258; eidem, US 4399132 (1982, 1983 both to Am. Cyanamid); eidem, J. Antibiot. 36, 179 (1983). Improved prepn of sodium salt: K. Naito et al., EP 145395 (1985 to Takeda). In vitro antibacterial spectrum: M. Hikada et al., J. Antimicrob. Chemother. 18, 585 (1986). Toxicity study: S. Takita, Chemotherapy (Tokyo) 34, Suppl. 3, 96 (1986). Conference proceedings: Recent Adv. Chemother., Antimicrobial Sect. 2., Proc. 14th Int. Congr. Chemother., Kyoto 1985, J. Ishigami, Ed. (Univ. Tokyo Press, Tokyo, 1985) pp 887-908. Series of articles: Chemotherapy (Tokyo) 34, Suppl. 3, 1-732 (1986).

Vinorelbine CAS Registry Number: 71486-22-1 长春瑞滨

CAS Name: (2b,3b,4b,5a,12R,19a)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyla...
Literature References: Semi-synthetic Vinca alkaloid; structurally related to vinblastine, q.v. Prepn: JP Kokai 80 31096; N. Langlois et al., US 4307100 (1980, 1981 both to Agence Nat. Valorisation Recherche); P. Mangeney et al., Tetrahedron 35, 2175 (1979). Pharmacology: G. Mathé, P. Reizenstein, Cancer Lett. 27, 285 (1985). HPLC determn in biological fluids: F. Jehl et al., J. Chromatogr. 525, 225 (1990). Veterinary trial in dogs with spontaneous neoplasia: V. J. Poirier et al., J. Vet. Intern. Med. 18, 536 (2004). Symposium: Semin. Oncol. 16, Suppl. 4, 1-45 (1989). Review of early clinical development: M. Marty et al., Nouv. Rev. Fr. Hematol. 31, 77-84 (1989); of clinical pharmacokinetics: D. Leveque, F. Jehl, Clin. Pharmacokinet. 31, 184-197 (1996); of use in advanced non-small cell lung cancer: M. P. Curran, G. L. Plosker, Drugs Aging 19, 695-721 (2002).

Azlocillin CAS Registry Number: 37091-66-0 阿洛西林

CAS Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[[(2R)-[[(2-oxo-1-imidazolidinyl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: D-a-[(imidazo...
Literature References: Semi-synthetic, broad-spectrum acylureido penicillin. Prepn: H. Disselnkotter, K. G. Metzger, FR 2100682; eidem, US 3933795 (1971, 1976 both to Bayer); H. B. Konig et al., Eur. J. Med. Chem. - Chim. Ther. 17, 59 (1982). In vitro studies: D. Stewart et al., Antimicrob. Agents Chemother. 11, 865 (1977). In vitro and in vivo activity: G. K. Daikos et al., Curr. Chemother., Proc. 10th Int. Congr. Chemother., 1977 (Amer. Soc. Microbiol., Washington, D.C., 1978) 1, pp 626-8. Pharmacokinetics: P. Fiegel, K. Becker, Antimicrob. Agents Chemother. 14, 288 (1978). Comparison with other penicillins: J. M. Andrews, K. A. Bedford, ibid. 559. Clinical studies: H. Lode et al., Infection 5, 163 (1977); E. B. Helm et al., Dtsch. Med. Wochenschr. 102, 1211 (1977). Series of articles on antibacterial activity, pharmacology, and clinical trials: Arzneim.-Forsch. 29, 1915-2032 (1979); Infection 10, Suppl. 3, S121-S266 (1982); J. Antimicrob. Chemother. 11, Suppl. B, 1-239 (1983).

Mezlocillin CAS Registry Number: 51481-65-3 美洛西林

CAS Name: (2S,5R,6R)-3,3-Dimethyl-6-[[(2R)-[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional N...
Literature References: Semisynthetic, broad-spectrum antibiotic related to penicillins and azlocillin, q.v. Prepn: H. B. König et al., DE 2152967; eidem, US 3974142 (1973, 1976 both to Bayer). In vitro study: G. P. Bodey, T. Pan, Antimicrob. Agents Chemother. 11, 74 (1977). Pharmacokinetics: H. Lode et al., Infection 5, 163 (1977); S. J. Pancoast, H. C. Neu, Clin. Pharmacol. Ther. 24, 108 (1978). Clinical pharmacology: B. F. Issell et al., Antimicrob. Agents Chemother. 13, 180 (1978). Tissue concentration and efficacy: E. Helwing et al., Med. Klin. 74, 112 (1979). Series of articles on antibacterial activity, pharmacology, and clinical trials: Arzneim.-Forsch. 29, 1915-2032 (1979); Infection 10, Suppl. 3, S121-S266 (1982); J. Antimicrob. Chemother. 11, Suppl. C, 1-108 (1983).

Cefepime CAS Registry Number: 88040-23-7 头孢吡肟

CAS Name: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium inner salt
Additional Names...
Literature References: Semisynthetic, fourth generation cephalosporin antibiotic. Prepn: S. Aburaki et al., DE 3307550; eidem, US 4406899 (both 1983 to Bristol-Myers); and antibacterial activity: T. Naito et al., J. Antibiot. 39, 1092 (1986). In vitro comparative antimicrobial spectrum: N. J. Khan et al., Antimicrob. Agents Chemother. 26, 585 (1984); and b-lactamase stability: H. C. Neu et al., J. Antimicrob. Chemother. 17, 441 (1986). HPLC determn in plasma and urine: R. H. Barbhaiya et al., Antimicrob. Agents Chemother. 31, 55 (1987). Clinical evaluations in infection: N. Clynes et al., Diagn. Microbiol. Infect. Dis. 12, 257 (1989); S. Oster et al., Antimicrob. Agents Chemother. 34, 954 (1990). Review of clinical pharmacokinetics: M. P. Okamoto et al., Clin. Pharmacokinet. 25, 88-102 (1993).

Isoapo- b -erythroidine CAS Registry Number: 2581-07-9

Percent Composition: C 74.67%, H 6.27%, N 5.80%, O 13.26%
Literature References: Separation from apo-b-erythroidine: Sauvage et al., Science 109, 627 (1949); Sauvage, Boekelheide, J. Am. Chem. Soc. 72, 2062 (1950); Koniuszy, Folkers, ibid. 73, 333 (1951). Synthesis and structure: Blake et al., ibid. 87, 1397 (1965).

PMSF CAS Registry Number: 329-98-6 苄磺酰氟

CAS Name: Benzenemethanesulfonyl fluoride
Additional Names: phenylmethanesulfonyl fluoride; a-toluenesulfonyl fluoride
Percent Composition: C 48.27%, H 4.05%, F 10.91%, O 18.37%, S 18.41%
Literature References: Serine and cysteine protease inhibitor. Prepn: W. Davies, J. H. Dick, J. Chem. Soc. 1932, 483; and protease inhibition study: D. E. Fahrney, A. M. Gold, J. Am. Chem. Soc. 85, 997 (1963). Stability studies: G. T. James, Anal. Biochem. 86, 574 (1978). Analgesic effects and toxicity in rodents: C. Pinsky et al., Life Sci. 31, 1193 (1982). Neuropathologic effects in organophosphorus ester-induced delayed neuropathy in hens: C. Massicotte et al., Neurotoxicology 20, 749 (1999).

Tandospirone CAS Registry Number: 87760-53-0 坦度螺酮

CAS Name: (3aa,4b,7b,7aa)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
Additional Names: (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl...
Literature References: Serotonin (5-HT1A) receptor agonist. Prepn: K. Ishizumi et al., EP 82402; eidem, US 4507303 (1983, 1985 both to Sumitomo); idem et al., Chem. Pharm. Bull. 39, 2288 (1991). Behavioral pharmacology: C. A. Sannerud et al., Drug Alcohol Depend. 32, 195 (1993). Clinical efficacy in treatment of bulimia: H. Tamai et al., Int. J. Obes. 14, 289 (1990). Clinical evaluation of potential adverse effects: M. Suzuki et al., Jpn. J. Psychopharmacol. 13, 213 (1993); of abuse liability: S. M. Evans et al., J. Pharmacol. Exp. Ther. 271, 683 (1994). Review of pharmacology: P. A. Seymour et al., Prog. Clin. Biol. Res. 361, 453-460 (1990).