其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Erythromycin Lactobionate CAS Registry Number: 3847-29-8 乳糖酸阿奇霉素

CAS Name: 4-O-b-D-Galactopyranosyl-D-gluconic acid compd with erythromycin (1:1)
Trademarks: Erythrocin Lactobionate (Abbott)
Literature References: Semi-synthetic macrolide antibiotic prepd from erythromycin base and lactobiono-d-lactone in water-acetone: Hoffhine, US 2761859 (1956 to Abbott); alternate prepn and antibacterial activity: S. K. Dutta, K. S. Basu, US 4137397 (1979 to Jadavpur Univ.). Pharmacokinetics: R. L. Parsons et al., J. Int. Med. Res. 8, suppl. 2, 15 (1980).

Troleandomycin CAS Registry Number: 2751-09-9 竹桃霉素三乙酸酯

CAS Name: Oleandomycin triacetate ester
Additional Names: triacetyloleandomycinTrademarks: Cyclamycin (Wyeth); Wytrion (Wyeth); Evramycin (Wyeth); TAO (Roerig); Triocetin (OFF)
Percent Compo...
Literature References: Semi-synthetic macrolide antibiotic. Prepd from oleandomycin: Celmer et al., Antibiot. Annu. 1957-1958, p 476; GB 877730 (1958 to Pfizer); M. Khristov, N. Petkov, Farmatsiya (Sofia) 27, 1 (1977), C.A. 90, 23458c (1979). Review: S. Ross, Antimicrobial Therapy, B. M. Kagan, Ed. (Saunders, Philadelphia, 1970) pp 134-144.

Erythromycin Stearate CAS Registry Number: 643-22-1 硬脂酸红霉素

CAS Name: Erythromycin octadecanoate (salt)
Trademarks: Abboticine (Abbott); Bristamycin (BMS); Dowmycin E (Dow); Erypar (Parke-Davis); Eryprim (Scarium); Erythro S (Sanko); Erythrocin (Abbott)...
Literature References: Semi-synthetic macrolide antibiotic. Prepn: O. F. Walasek, US 2881163 (1959 to Abbott). Bioavailability: A.-S. Malmborg, J. Antimicrob. Chemother. 5, 591 (1979). Pharmacokinetics and tolerance: D. C. Shanson et al., ibid. 14, 157 (1984). Clinical efficacy in respiratory tract infections: J. P. Butler et al., Chemotherapy (Basel) 25, 367 (1979); in acute otitis media: C. Rosen et al., Acta Otolaryngol. (Stockholm) Suppl. 407, 23 (1984). Prepn of erythromycin stearate (ester): Booth, Murray, US 2862921 (1958 to Upjohn).

Erythromycin Glucoheptonate CAS Registry Number: 23067-13-2 红霉素葡庚糖酸盐

CAS Name: D-glycero-D-gulo-Heptonic acid compd with erythromycin (1:1)
Additional Names: erythromycin glucoheptonic acid salt; erythromycin gluceptate
Trademarks: Ilotycin Gluceptate (Lilly)...
Literature References: Semi-synthetic macrolide antibiotic. Prepn: Shepler, US 2852429 (1958 to Lilly).

Erythromycin Propionate CAS Registry Number: 134-36-1 红霉素丙酸酯

CAS Name: Erythromycin 2'-propanoate
Additional Names: propionylerythromycin; monopropionylerythromycin
Trademarks: Propiocine (Hoechst)
Percent Composition: C 60.81%, H 9.06%, N 1.77%, O...
Literature References: Semi-synthetic macrolide antibiotic. Prepn: V. C. Stephens, US 2993833 (1961 to Lilly); V. C. Stephens, J. W. Conine, Antibiot. Annu. 1958-59, 346. Pharmacology and toxicology: C. Lee et al., ibid. 354. Clinical studies: R. S. Griffith, ibid. 364; D. M. Perry et al., ibid. 375. Clinical pharmacokinetics: M. Ducci et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 494 (1981). HPLC determn in plasma: W. Xiao et al., J. Chromatogr. B 817, 153 (2005).

Clarithromycin CAS Registry Number: 81103-11-9 克拉霉素

CAS Name: 6-O-MethylerythromycinTrademarks: Biaxin (Abbott); Clarosip (Grñenthal); Clathromycin (Taisho); Cyllind (Abbott); Klacid (Abbott); Klaricid (Abbott); Macladin (Guidotti); Naxy (Sanofi Wi...
Literature References: Semisynthetic macrolide antibiotic; derivative of erythromycin, q.v. Prepn: Y. Watanabe et al., EP 41355; eidem, US 4331803 (1981, 1982 both to Taisho); and in vitro antibacterial activity: S. Morimoto et al., J. Antibiot. 37, 187 (1984). In vitro and in vivo antibacterial activity: P. B. Fernandes et al., Antimicrob. Agents Chemother. 30, 865 (1986). Comparative antibacterial spectrum in vitro: C. Benson et al., Eur. J. Clin. Microbiol. 6, 173 (1987); H. M. Wexler, S. M. Finegold, ibid. 492. HPLC determn in biological fluids: D. Croteau et al., J. Chromatogr. 419, 205 (1987); in plasma: H. Amini, A. Ahmadiani, J. Chromatogr. B 817, 193 (2005). Acute toxicity study: S. Abe et al., Chemotherapy (Tokyo) 36, Suppl. 3, 274 (1988). Symposium on pharmacology and comparative clinical studies: J. Antimicrob. Chemother. 27, Suppl. A, 1-124 (1991). Comprehensive description: I. I. Salem, Anal. Profiles Drug Subs. Excip. 24, 45-85, (1996).

Azithromycin CAS Registry Number: 83905-01-5 阿奇霉素

CAS Name: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dime...
Literature References: Semi-synthetic macrolide antibiotic; related to erythromycin A, q.v. Prepn: BE 892357; G. Kobrehel, S. Djokic, US 4517359 (1982, 1985 both to Sour Pliva); of the crystalline dihydrate: D. J. M. Allen, K. M. Nepveux, EP 298650; eidem, US 6268489 (1989, 2001 both to Pfizer). Antibacterial spectrum: S. C. Aronoff et al., J. Antimicrob. Chemother. 19, 275 (1987); and mode of action: J. Retsema et al., Antimicrob. Agents Chemother. 31, 1939 (1987). Series of articles on pharmacology, pharmacokinetics, and clinical experience: J. Antimicrob. Chemother. 31, Suppl. E, 1-198 (1993). Clinical trial in prevention of Pneumocystis carinii pneumonia in AIDS patients: M. W. Dunne et al., Lancet 354, 891 (1999). Review of pharmacology and clinical efficacy in pediatric infections: H. D. Langtry, J. A. Balfour, Drugs 56, 273-297 (1998).

Flomoxef CAS Registry Number: 99665-00-6 氟氧头孢

CAS Name: (6R-cis)-7-[[[(Difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional ...
Literature References: Semi-synthetic oxacephalosporin antibiotic. Prepn: T. Tsuji et al., BE 898541; eidem, US 4532233 (1984, 1985 both to Shionogi); eidem, J. Antibiot. 38, 466 (1985). In vitro activity and b-lactamase stability: H. C. Neu, N.-X. Chin, Antimicrob. Agents Chemother. 30, 638 (1986).

Aspoxicillin CAS Registry Number: 63358-49-6 阿扑西林

CAS Name: (2R)-N-Methyl-D-asparaginyl-N-[(2S,5R,6R)-2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl]-D-2-(4-hydroxyphenyl)glycinamide
Additional Names: 6-[D-2-(D-2-amino-3-N-me...
Literature References: Semisynthetic penicillin. Prepn: M. Kawazu et al., DE 2638067; eidem, US 4053609 (both 1977 to Tanabe); prepn and antibacterial activity: M. Wagatsuma et al., J. Antibiot. 36, 147 (1985). Mechanism of action study: T. Nishino et al., Chemotherapy (Tokyo) 33, 132 (1985), C.A. 103, 34792v (1985). Toxicological study: M. Takeshita et al., Oyo Yakuri 30, 687 (1985), C.A. 104, 101990u (1986). HPLC determn in serum: J. Knöller et al., Zentralbl. Bakteriol. Mikrobiol. Hyg. 265, 176 (1987). Clinical evaluation in ocular infections: M. Ooishi et al., Acta Med. Biol. 34, 1 (1986). Series of articles on antibacterial activity, pharmacology and clinical efficacy: Chemotherapy (Tokyo) 32, Suppl. 2, 1-791 (1984).

Semduramicin CAS Registry Number: 113378-31-7 生度米星

CAS Name: (2R,3S,4S,5R,6S)-Tetrahydro-2,4-dihydroxy-6-[(1R)-1-[(2S,5R,7S,8R,9S)-9-hydroxy-2,8-dimethyl-2-[(2S,2'R,3'S,5R,5'R)-octahydro-2-methyl-5'-[(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimet...
Literature References: Semi-synthetic polyether ionophore antibiotic. Prepn: A. C. Goudie, N. D. A. Walshe, EP 255335; eidem, US 4804680 (1988, 1989 both to Pfizer). LC determn in poultry liver: J. F. Ericson et al., J. AOAC Int. 77, 577 (1994). Metabolism and tissue residue studies in broiler chickens: M. J. Lynch et al., ACS Symp. Ser. 503, 49-69 (1992). Anticoccidial effects in chickens: M. E. McKenzie et al., Poult. Sci. 72, 2052 (1993); N. B. Logan et al., ibid., 2058.