其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Hetacillin CAS Registry Number: 3511-16-8 海他西林

CAS Name: (2S,5R,6R)-6-[(4R)-2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: 6-(2,2-dimethyl-5-oxo-4-pheny...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn and structure: Hardcastle et al., J. Org. Chem. 31, 897 (1966); Johnson, Panetta, US 3198804 (1965 to Bristol-Myers). Pharmacology: Kirby, Kind, Ann. N.Y. Acad. Sci. 145, 291 (1967); Ueda et al., J. Antibiot. 20B, 206 (1967), C.A. 69, 95016w (1968). Stability studies: Saccani, Pansera, Boll. Chim. Farm. 107, 640 (1968). Epimerization at C-6 to epihetacillin: Johnson et al., Tetrahedron Lett. 1968, 1903.

Propicillin CAS Registry Number: 551-27-9 丙匹西林

CAS Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(1-oxo-2-phenoxybutyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: 6-(a-phenoxybutyramido)penicillanic acid; a-phenoxy...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn from 6-aminopenicillanic acid: GB 877120 (1961 to Beecham); of salts: Perron et al., J. Am. Chem. Soc. 82, 3934 (1960); Glombitza, Ann. 673, 166 (1964). Metabolism in humans: M. Cole et al., Antimicrob. Agents Chemother. 3, 463 (1973). TLC determn: S. Hendrickx et al., J. Chromatogr. 291, 211 (1984).

Carbenicillin CAS Registry Number: 4697-36-3 羧苄西林

CAS Name: (2S,5R,6R)-6-[(Carboxyphenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn of monopotassium salt: Hobbs, US 3142673 (1964 to Pfizer); of disodium salt: BE 646991; Brain, Nayler, US 3282926 (1964, 1966 both to Beecham). Activity studies and pharmacology: Naumann, Kempf, Arzneim.-Forsch. 19, 1222 (1969). Chemistry and mode of action: Butler et al., J. Infect. Dis. 122, Suppl., 81 (1970). Clinical data: Hoffler et al., ibid. 1233; Gritz, Naumann, ibid. 1237. Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Apalcillin CAS Registry Number: 63469-19-2 萘啶青霉素

CAS Name: (2S,5R,6R)-6-[[(2R)-[[(4-Hydroxy-1,5-naphthyridin-3-yl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Percent Composition: C...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn of the potassium salt: H. Tobiki et al., ZA 7205865; eidem, US 3864329 (1973, 1975 both to Sumitomo); of the sodium salt: Y. Hirotada et al., US 4005075 (1977 to Sumitomo); H. Tobiki et al., Yakugaku Zasshi 100, 49 (1980), C.A. 93, 95179x (1980). Microbiological evaluation: H. Noguchi et al., Antimicrob. Agents Chemother. 9, 262 (1976). Analytical studies: I. Umeda et al., Yakugaku Zasshi 99, 717 (1979), C.A. 92, 11287z (1980). Series of articles on pharmacology, exptl and clinical effects: Chemotherapy (Tokyo) 26, Suppl. 2, 111-223 (1978). Pharmacokinetics in man: U. Busch et al., Arzneim.-Forsch. 32, 1131 (1982).

Methicillin Sodium CAS Registry Number: 132-92-3 甲氧西林钠

CAS Name: (2S,5R,6R)-6-[(2,6-Dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt
Additional Names: 6-(2,6-dimethoxybenzamido)penicilla...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn starting with 6-aminopenicillanic acid: Doyle et al., J. Chem. Soc. 1962, 1457; Doyle et al., US 2951839 (1960); Glombitza, Ann. 673, 166 (1964). Physical-chemical properties: Cotta-Ramusino, Intonti, Farmaco Ed. Prat. 16, 227 (1961).

Fenbenicillin CAS Registry Number: 1926-48-3 芬贝西林

CAS Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyphenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: 3,3-dimethyl-7-oxo-6-(2-phenoxy-2-phenylacetamido)-4...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: GB 877120 (1961 to Beecham). Bacteriological and pharmacological properties: Rollo, Burley, Br. Med. J. I, 76 (1962).

Penamecillin CAS Registry Number: 983-85-7 培那西林

CAS Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (acetyloxy)methyl ester
Additional Names: penicillin G hydroxymethyl ester ac...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: A. B. A. Jansen, T. J. Russell, J. Chem. Soc. 1965, 2127; eidem, GB 1003479 (1965 to John Wyeth Brother); eidem, US 3250679 (1966 to Am. Home).

Cyclacillin CAS Registry Number: 3485-14-1 环己西林

CAS Name: (2S,5R,6R)-6-[[(1-Aminocyclohexyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: 6-(1-aminocyclohexanecarboxamido)penicillani...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: Alburn et al., US 3194802; C. A. Robinson, J. J. Nescio, DE 1800698; eidem, US 3478018 (1965, 1969, 1969, all to Am. Home Prods.). Activity studies: Rosenman et al., Antimicrob. Agents Chemother. 1967, 590; Hopper et al., ibid. 597; Yurchenco et al., ibid. 602; Chemotherapy 15, 209 (1970). Metabolic studies: Poole, J. Pharm. Sci. 59, 1255 (1970); Tucker et al., Toxicol. Appl. Pharmacol. 19, 361 (1971). Physicochemical data: Alburn et al., Antimicrob. Agents Chemother. 1967, 586; Hou, Poole, J. Pharm. Sci. 58, 1510 (1969); Poole, Bahal, ibid. 59, 1265 (1970).

Bacampicillin CAS Registry Number: 50972-17-3 巴氨西林

CAS Name: (2S,5R,6R)-6-[[(2R)-Aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 1-[(ethoxycarbonyl)oxy]ethyl ester
Additional Names: (2S,5R,6R)-6-[...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: B. A. Ekstrom, B. O. H. Sjoberg, DE 2144457; eidem, US 3873521 and US 3939270 (1972, 1975 and 1976 all to Astra). In vitro and in vivo study: N. O. Bodin et al., Antimicrob. Agents Chemother. 8, 518 (1975). Pharmacokinetics: M. Rozencweig et al., Clin. Pharmacol. Ther. 19, 592 (1976); T. Bergan, Antimicrob. Agents Chemother. 13, 971 (1978). Animal studies: C. Carbon et al., Scand. J. Infect. Dis. Suppl. 14, 127 (1978); T. Bergan, I. Versland, ibid. 135; U. Forsgren et al., ibid. 207. Clinical studies: P. V. Maesen et al., J. Antimicrob. Chemother. 2, 279 (1976); J. Sjövall, J. Int. Med. Res. 5, 313 (1977); C. Ekedahl et al., Scand. J. Infect. Dis. Suppl. 14, 279 (1978). Toxicology: M. Edanaga et al., Chemotherapy (Tokyo) 27, Suppl. 4, 17 (1979).

Oxacillin CAS Registry Number: 66-79-5 苯唑西林

CAS Name: (2S,5R,6R)-3,3-Dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: 5-methyl-3-phenyl-4-isoxazolylp...
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: Doyle, Nayler, US 2996501 (1961); Doyle et al., Nature 192, 1183 (1961). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).