其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bifenox CAS Registry Number: 42576-02-3 5-(2,4-二氯苯氧基)-2-硝基苯甲酸甲酯

CAS Name: 5-(2,4-Dichlorophenoxy)-2-nitrobenzoic acid methyl ester
Additional Names: methyl 5-(2,4-dichlorophenoxy)-2-nitrobenzoate; 2,4-dichlorophenyl 3-(methoxycarbonyl)-4-nitrophenyl etherTr...
Literature References: Pre-emergence herbicide. Prepn and herbicidal activity: BE 749444; R. J. Thiessen, US 3652645 (1970, 1972 both to Mobil). Comparison with other herbicides in corn: W. M. Dest et al., Proc. Annu. Meet. Northeast. Weed Sci. Soc. 27, 31 (1973). Metabolism in soil, plants: G. R. Leather, C. L. Foy, Pestic. Biochem. Physiol. 7, 437 (1977). Brief description: R. H. Dreger, Weeds Today 8(2), 18 (1977). Review: P. J. Kruger et al., Proc. 12th Br. Weed Control Conf. 2, 839-845 (1974).

Butralin CAS Registry Number: 33629-47-9 丁烯酯甲酸

CAS Name: 4-(1,1-Dimethylethyl)-N-(1-methylpropyl)-2,6-dinitrobenzenamine
Additional Names: N-sec-butyl-4-tert-butyl-2,6-dinitroaniline; dibutalinTrademarks: Amexine (CFPI); Tamex (CFPI)
Per...
Literature References: Pre-emergence herbicide. Prepn: J. J. Damiano, DE 2058201; idem, US 3672866 (1971, 1972 both to Amchem). Activity: S. R. McLane et al., Proc. South. Weed Sci. Soc. 24, 58 (1971). Soil persistence and metabolism: P. C. Kearney et al., J. Agric. Food Chem. 22, 856 (1974). Photochemistry: J. R. Plimmer, U. I. Klingebiel, ibid. 689.

Clomazone CAS Registry Number: 81777-89-1 异恶草酮

CAS Name: 2-[(2-Chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone
Additional Names: dimethazoneTrademarks: Command (FMC)
Percent Composition: C 60.13%, H 5.89%, Cl 14.79%, N 5.84%, O 13.35...
Literature References: Pre-emergence herbicide; inhibits biosynthesis of photosynthetic pigments in susceptible species. Prepn: J. H. Chang, BE 889040; idem, US 4405357 (1982, 1983 both to FMC). Use on soybeans: M. P. Mascianica, Proc. Annu. Meet. Northeast. Weed Sci. Soc. 39, 25 (1985); on white potatoes: C. C. Kupatt et al., ibid. 166. Fate in soil: T. L. Mervosh et al., J. Agric. Food Chem. 43, 537 (1995). Review of properties and analytical methods: A. W. Chen in Comprehensive Analytical Profiles of Important Pesticides, J. Sherma, T. Cairns, Eds. (CRC Press, Boca Raton, 1993) pp 131-148.

Isoxaflutole CAS Registry Number: 141112-29-0 异恶唑草酮

CAS Name: (5-Cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone
Additional Names: 5-cyclopropyl-1,2-oxazol-4-yl a,a,a-trifluoro-2-mesyl-p-tolyl ketone; 5-cycloprop...
Literature References: Pre-emergent herbicide designed for use in maize. Disrupts pigment biosynthesis via an inhibition of 4-hydroxyphenylpyruvate dioxygenase. Prepn: P. A. Cain et al., EP 527036 (1993 to Rhone-Poulenc). Properties and biological activity: B. M. Luscombe et al., Brighton Crop Prot. Conf. - Weeds 1995, 35. Weed control in maize: B. M. Luscombe, K. E. Pallett, Pestic. Outlook 7, 29 (1996). Mechanism of action: K. E. Pallett et al., Pestic. Sci. 50, 83 (1997). Soil persistence: J. Rouchaud et al., Bull. Environ. Contam. Toxicol. 60, 577 (1998).

Diclosulam CAS Registry Number: 145701-21-9 双氯磺草胺

CAS Name: N-(2,6-Dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide
Additional Names: XDE-564
Trademarks: Strongarm (Dow AgroSci.)
Percent Composition: C 38.4...
Literature References: Pre-emergent, soil-applied herbicide for broadleaf weed control in peanuts and soybeans. Prepn: J. C. Van Heertum et al., EP 343752; eidem, US 5163995 (1989, 1992 both to DowElanco). Field study in peanuts: W. A. Bailey et al., Weed Technol. 13, 450, 771 (1999); W. J. Grichar et al., Peanut Sci. 26, 23 (1999). Field trial in soybeans: D. R. Shaw et al., Weed Technol. 13, 791 (1999).

Bromal CAS Registry Number: 115-17-3 三溴乙醛

CAS Name: Tribromoacetaldehyde
Percent Composition: C 8.56%, H 0.36%, Br 85.39%, O 5.70%
Literature References: Preparation from ethanol and bromine: Löwig, Ann. 3, 288 (1832); from chloral and a bromide: Müller, US 2053964 (1936 to Winthrop); from paraldehyde and bromine: Long, Howard, Org. Synth. 17, 18 (1937).

Sulfasomizole CAS Registry Number: 632-00-8 磺胺异噻唑

CAS Name: 4-Amino-N-(3-methyl-5-isothiazolyl)benzenesulfonamide
Additional Names: 3-methyl-5-sulfanilamidoisothiazole; 5-p-aminobenzenesulfonamido-3-methylisothiazole; 5-sulfanilamido-3-methyli...
Literature References: Preparation from N-acetylsulfanilyl chloride and 5-amino-3-methylisothiazole in pyridine followed by deacetylation in 2N NaOH: Adams, Slack, J. Chem. Soc. 1959, 3070; Adams et al., Nature 186, 221 (1960); GB 835753 (1960 to May Baker).

Benzyl Ethyl Ether CAS Registry Number: 539-30-0 苄基乙基醚

CAS Name: (Ethoxymethyl)benzene
Percent Composition: C 79.37%, H 8.88%, O 11.75%
Literature References: Preparation from sodium ethoxide and benzyl bromide: Letsinger, Pollart, J. Am. Chem. Soc. 78, 6079 (1956); by reduction of benzaldehyde diethyl acetal with LiAlH4-AlCl3: Eliel, Rerick, J. Org. Chem. 23, 1088 (1958).

Hydroxycodeinone CAS Registry Number: 508-54-3 14-羟基可待因酮

CAS Name: 5a-7,8-Didehydro-4,5a-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Additional Names: 14-hydroxycodeinone
Percent Composition: C 68.99%, H 6.11%, N 4.47%, O 20.42%
Literature References: Preparation from thebaine: Freund, Speyer, J. Prakt. Chem. 94, 135 (1916). From codeine: Merck, DE 411530; Frdl. 15, 1516; K. W. Bentley, The Chemistry of the Morphine Alkaloids (Oxford, 1954). Improved synthesis: F. M. Hauser et al., J. Med. Chem. 17, 1117 (1974). Isoln from Papaver bracteatum Lindl.: H. G. Theuns et al., Phytochemistry 16, 753 (1977).

Stenbolone CAS Registry Number: 5197-58-0 司腾勃龙

CAS Name: (5a,17b)-17-Hydroxy-2-methylandrost-1-en-3-one
Additional Names: 2-methyl-5a-androst-1-en-17b-ol-3-one; 2-methyl-17b-hydroxy-5a-androst-1-en-3-one; stenobolone (rescinded USAN)
Per...
Literature References: Preparation of free alcohol and acetate: R. Mauli et al., J. Am. Chem. Soc. 82, 5494 (1960); Kaspar et al., DE 1096356 (1961 to Schering AG), C.A. 55, 27440b (1961); R. E. Counsell et al., J. Org. Chem. 27, 248 (1962); GB 925849 (1963 to Syntex).