其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Levomethadyl Acetate CAS Registry Number: 1477-40-3 [(3S,6S)-6-二甲氨基-4,4-二苯基-庚烷-3-基]乙酸酯

CAS Name: (aS)-b-[(2S)-2-(Dimethylamino)propyl]-a-ethyl-b-phenylbenzeneethanol acetate (ester)
Additional Names: (-)-6-(dimethylamino)-4,4-diphenyl-3-heptanol acetate (ester); a-l-acetylmethado...
Literature References: Longest-acting enantiomer of methadyl acetate, q.v. Duration of action due to active metabolites. Prepn: A. Pohland et al., J. Am. Chem. Soc. 71, 460 (1949). Synthesis of metabolites: F. I. Carroll et al., J. Org. Chem. 41, 3521 (1976). Metabolism in rats: G. L. Henderson et al., Drug Metab. Dispos. 5, 321 (1977); M. Man et al., ibid. 8, 55 (1980); in man: B. S. Finkle et al., J. Anal. Toxicol. 6, 100 (1982). Determn of LAAM and metabolites by HPLC: C.-H. Kiang et al., J. Chromatogr. 222, 81 (1981); by GLC: K. Verebey et al., ibid. 343, 339 (1985). Analgesic activity in mice: N. B. Eddy et al., J. Org. Chem. 17, 321 (1952); in man: A. S. Keats, H. K. Beecher, J. Pharmacol. Exp. Ther. 105, 210 (1952). Pharmacology in monkeys: S. J. Mule, A. L. Misra, Ann. N.Y. Acad. Sci. 311, 199 (1978). Comparison with methadone in the treatment of heroin addiction: T. J. Crowley et al., Psychopharmacology 86, 458 (1985). Review of use in treatment of narcotic addiction: J. D. Blaine et al., Ann. N.Y. Acad. Sci. 362, 101-115 (1981).

Beryllium Hydride CAS Registry Number: 7787-52-2

Percent Composition: Be 81.71%, H 18.28%
Literature References: Lower purity material prepd by treating dimethylberyllium with LiAlH4 in ether: Barbaras et al., J. Am. Chem. Soc. 73, 4585 (1951); higher purity by pyrolysis of di-tert-butylberyllium: Coates, Glocking, J. Chem. Soc. 1954, 2526; Head et al., J. Am. Chem. Soc. 79, 3687 (1957); from triphenyl phosphine and beryllium borohydride: Banford, Coates, J. Chem. Soc. 1964, 5591.

Methylcytisine CAS Registry Number: 486-86-2 N-甲基金雀花碱

CAS Name: (1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Additional Names: caulophylline; 12-methylcytisine; N-methylcytisine
Percent Composition: C 7...
Literature References: Lupine alkaloid of the quinolizidine type; occurring most abundantly in Leguminosae. Bioactive principle of blue cohosh, q.v. Isoln from Caulophyllum thalictroides Michx., Berberidaceae: F. B. Power, A. H. Salway, J. Chem. Soc. 103, 191 (1913); M. S. Flom et al., J. Pharm. Sci. 56, 1515 (1967); from Baptisia australis (L.) R. Br., Leguminosae: L. Marion, J. Ouellet, J. Am. Chem. Soc. 70, 691 (1948). Absolute configuration: S. Okuda et al., Chem. Pharm. Bull. 13, 491 (1965). Crystal structure: A. A. Freer et al., Acta Crystallogr. C43, 1119 (1987). Pharmacology: H. C. Ferguson, L. D. Edwards, J. Am. Pharm. Assoc. Sci. Ed. 43, 16 (1954). Toxicity study: R. B. Barlow, L. J. McLeod, Br. J. Pharmacol. 35, 161 (1969). Binding to nicotinic and muscarinic receptors: T. Schmeller et al., J. Nat. Prod. 57, 1316 (1994).

Valacyclovir CAS Registry Number: 124832-26-4 伐昔洛韦

CAS Name: L-Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester
Additional Names: L-valine ester with 9-[(2-hydroxyethoxy)methyl]guanine; valaciclovir; ValACV
Percent Comp...
Literature References: L-Valine ester prodrug of acyclovir, q.v. Prepn: T. A. Krenitsky et al., EP 308065; L. M. Beauchamp, US 4957924 (1989, 1990 both to Wellcome). Evaluation as prodrug: L. M. Beauchamp et al., Antiviral Chem. Chemother. 3, 157 (1992). Clinical pharmacokinetics: S. Weller et al., Clin. Pharmacol. Ther. 54, 595 (1993). Review of pharmacology and clinical efficacy in herpes virus infections: C. M. Perry, D. Faulds, Drugs 52, 754-772 (1996). Clinical trial to prevent cytomegalovirus disease in renal transplantation: D. Lowance et al., N. Engl. J. Med. 340, 1462 (1999); to prevent transmission of genital herpes: L. Corey et al., ibid. 350, 11 (2004).

Nemadectin CAS Registry Number: 102130-84-7 奈马克丁

CAS Name: [6R,23S,25S(E)]-5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-hydroxymilbemycin B
Additional Names: antibiotic S-541APercent Composition: C 70.56%, H 8.55%, O 20.89%
Literature References: Macrocyclic antibiotic produced by Streptomyces cyaneogriseus ssp. noncyanogenus and Streptomyces thermoachaensis. Structurally related to the milbemycins and the avermectins, q.q.v. Isoln: I. B. Wood et al., EP 170006; I. B. Wood, J. A. Pankavich, US 4869901 (1986, 1989 both to Am. Cyanamid). Chemical and structural characterization: G. T. Carter et al., Chem. Commun. 1987, 402; G. T. Carter et al., J. Antibiot. 41, 519 (1988). NMR spectroscopy: S. Rajan, G. W. Stockton, Magn. Reson. Chem. 27, 437 (1989). Antiparasitic activity in horses: E. T. Lyons et al., Am. J. Vet. Res. 50, 970 (1989); in dogs: M. E. Doscher et al., Vet. Parasitol. 34, 255 (1989); in sheep: J. A. Pankavich et al, Vet. Rec. 130, 241, (1992).

Chlorothricin CAS Registry Number: 34707-92-1 氯丝菌素

Percent Composition: C 62.85%, H 6.65%, Cl 3.71%, O 26.79%
Literature References: Macrolide antibiotic active against gram-positive bacteria. Isolated together with its dechloro analog from Tü 99, a strain of Streptomyces antibioticus: Keller-Schierlein et al., Helv. Chim. Acta 52, 127 (1969). Degradation products studies: Muntwyler et al., ibid. 53, 1544 (1970). Structure: Muntwyler, Keller-Schierlein, ibid. 55, 2071 (1972). Non-competitive inhibitor of pyruvate carboxylase: P. W. Schindler, H. Zaehner, Arch. Mikrobiol. 82, 66, (1972); P. W. Schindler, M. C. Scrutton, ibid. 55, 543 (1975). Biosynthetic studies: O. Mascaretti et al., J. Nat. Prod. 42, 455 (1979); eidem, Biochemistry 20, 919 (1981). Partial synthesis of the aglycone, chlorothricolide: R. E. Ireland, W. J. Thompson, J. Org. Chem. 44, 3041 (1979); R. E. Ireland et al., ibid. 46, 4863 (1981); W. R. Roush, S. E. Hall, J. Am. Chem. Soc. 103, 5200 (1981). Alternate synthetic approach: R. E. Ireland, M. D. Varney, J. Org. Chem. 51, 635 (1986). Review: Keller-Schierlein, Fortschr. Chem. Org. Naturst. 30, 394-396 (1973); H. G. Floss, C.-J. Chang, Antibiotics vol. IV, J. W. Corcoran, Ed. (Springer-Verlag, New York, 1981) pp 193-214.

Rokitamycin CAS Registry Number: 74014-51-0 罗他霉素

CAS Name: Leucomycin V 4B-butanoate 3B-propanoate
Additional Names: 3''-propionylleucomycin A5; 5-[O-(2,6-dideoxyhexopyranosyl)-(1®4)-3,6-dideoxy-3-dimethylamino-b-D-glucopyranosyloxy]-6-formyl...
Literature References: Macrolide antibiotic active against Mycoplasma and macrolide resistant strains of Staphylococcus aureus and Streptococcus pyogenes. Prepn: H. Sakakibara et al., DE 2918954 corresp to US 4242504 (1979, 1980 both to Toyo Jozo); eidem, J. Antibiot. 34, 1001 (1981). Series of articles on antibacterial activity, pharmacology, metabolism, toxicology: Chemotherapy (Tokyo) 32, Suppl. 6, 1-627 (1984). Toxicity data: K. Matsumoto et al., ibid. 138.

Leucomycins CAS Registry Number: 1392-21-8 吉他霉素

Additional Names: KitasamycinTrademarks: Ayermicina (Ayerst); Sineptina (Antibioticos); Stereomycine (Toraude; Ayerst); Syneptine (Toraude)
Literature References: Macrolide antibiotic complex similar to carbomycin, q.v. and erythromycin, q.v., produced by Streptomyces kitasatoensis Hata: T. Hata et al., J. Antibiot. 6A, 87 (1953); Sano, ibid. 7A, 93 (1954). Early work performed on a mixture of at least six components, A1, A2, B1-B4, of which A1 was the most biologically active: J. Abe et al., J. Chem. Soc. Jpn. Pure Chem. Sect. 81, 969 (1960); T. Watanabe et al., Bull. Chem. Soc. Jpn. 33, 1100, 1104 (1960). Leucomycin isolated from an improved strain of S. kitasatoensis is a mixture of at least eight biologically active components, A1 and new substances A3-A9: Hata et al., US 3535309 (1970 to Kitasato Institute and Toyo Jozo). Leucomycins A1, A3-A9, U and V are substituted variations of the structure represented below. Structure of A1: T. Watanabe et al., Angew. Chem. 76, 792 (1964); T. Hata et al., Chem. Pharm. Bull. 15, 358 (1967); of A3: S. Omura et al., Tetrahedron Lett. 1967, 609, 1267; of A4 through A9: eidem, J. Antibiot. 20A, 234 (1967); 21, 272 (1968). Conformation: eidem, Tetrahedron 28, 2839 (1972). Revised configuration at C-9: L. A. Freiberg et al., J. Org. Chem. 39, 2474 (1974). Liquid chromatography of A1, A3-9, U, V: S. Omura et al., J. Antibiot. 26, 795 (1973). Antibacterial and antimycoplasmal activity: Iwata, Akiba, ibid. 15A, 258 (1962); Omura et al., ibid. 21, 532 (1968); 25, 105 (1972). In vitro and preliminary clinical studies: B. C. Stratford, S. Dixson, Med. J. Aust. 1, 1029 (1974). Antimicrobial transformation of A5 to V: K. Singh, S. Rakhit, ibid. 32, 78 (1979). Biosynthesis: C. Kitao et al., ibid. 32, 1055 (1979); S. Omura et al., ibid. 36, 611 (1983). Reviews: Desvignes, Ann. Pharm. Fr. 21, 569 (1963); Toju, Omura, "Chemical and Biological Studies on Leucomycins (Kitasamycins)" in Drug Action and Drug Resistance in Bacteria vol. I, S. Mitsuhashi, Ed. (University Park Press, Baltimore, 1971) pp 267-291; Keller-Schierlein in Fortschr. Chem. Org. Naturst. 30, 313-460 (1973); S. Omura, A. Nakagawa, J. Antibiot. 28, 401-433 (1975).

Neomethymycin CAS Registry Number: 497-73-4 新酒霉素

CAS Name: (12R)-10-Deoxy-12-hydroxymethymycin
Percent Composition: C 63.94%, H 9.23%, N 2.98%, O 23.85%
Literature References: Macrolide antibiotic found in the mother liquors from methymycin, q.v. Differs from methymycin only in the location of one hydroxyl group, which results in marked changes in chemical behavior: Djerassi, Halpern, J. Am. Chem. Soc. 79, 2022, 3926 (1957); Tetrahedron 3, 255 (1958). Production from Streptomyces venezuelae cultures: Dutcher et al., US 2916486 (1959 to Olin Mathieson). Synthesis of the aglycone, neomethynolide: J. Inanago et al., Chem. Lett. 1981, 1415.

Tylosin CAS Registry Number: 1401-69-0 泰乐菌素

Trademarks: Tylan (Elanco)
Percent Composition: C 60.31%, H 8.47%, N 1.53%, O 29.69%
Literature References: Macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand: Hamill et al., Antibiot. Chemother. 11, 328 (1961); eidem, US 3178341 (1965 to Lilly). Prodn in batch and chemostat cultures: P. P. Gray, S. Bhuwapathanapun, Biotechnol. Bioeng. 22, 1785 (1980). Partial structure: Morin, Gorman, Tetrahedron Lett. 1964, 2339. Structure: Morin et al., ibid. 1970, 4737; Achenbach et al., Ber. 108, 2481 (1975). Configurational study: S. Omura et al., Tetrahedron Lett. 1977, 1045. Abs config: eidem, J. Antibiot. 33, 915 (1980); N. D. Jones et al., ibid. 35, 420 (1982). Synthesis of tylonolide, the aglycone: S. Masamune et al., J. Am. Chem. Soc. 98, 7874 (1976); K. Tatsuta et al., Tetrahedron Lett. 22, 3997 (1981). Relationship of ribosomal binding and antibacterial properties: J. W. Corcoran et al., J. Antibiot. 30, 1012 (1977). Biosynthesis studies: E. T. Seno et al., Antimicrob. Agents Chemother. 11, 455 (1977); S. Omura et al., J. Antibiot. 31, 254 (1978).